The structural and biochemical foundations of thiamin biosynthesis.
The structural and biochemical foundations of thiamin biosynthesis.
复制标题
DOI：
10.1146/annurev.biochem.78.072407.102340
复制
发表时间：
2009
影响因子：
16.6
通讯作者：
Ealick SE
中科院分区：
文献类型：
--
作者：
Jurgenson CT;Begley TP;Ealick SE
硫胺素由大多数原核生物和真核生物如酵母和植物合成。在所有情况下，噻唑和嘧啶部分在途径的单独分支中合成，并偶联形成硫胺素磷酸盐。最后一个磷酸化产生硫胺素焦磷酸盐，辅因子的活性形式。在过去的十年左右，生物化学和结构研究已经阐明了细菌中硫胺素生物合成途径的大部分细节。噻唑的形成需要六种基因产物，嘧啶的形成需要两种。相比之下，酵母中硫胺素生物合成途径的细节才刚刚开始出现。噻唑的生物合成仅需要一种基因产物，嘧啶的生物合成仅需要一种基因产物。硫胺素也可以被运输到细胞中，并可以通过几种途径被回收。此外，两个硫胺素降解酶的特点，其中之一是连接到一个新的补救途径。
Thiamin is synthesized by most prokaryotes and by eukaryotes such as yeast and plants. In all cases, the thiazole and pyrimidine moieties are synthesized in separate branches of the pathway and coupled to form thiamin phosphate. A final phosphorylation gives thiamin pyrophosphate, the active form of the cofactor. Over the past decade or so, biochemical and structural studies have elucidated most of the details of the thiamin biosynthetic pathway in bacteria. Formation of the thiazole requires six gene products, and formation of the pyrimidine requires two. In contrast, details of the thiamin biosynthetic pathway in yeast are only just beginning to emerge. Only one gene product is required for the biosynthesis of the thiazole and one for the biosynthesis of the pyrimidine. Thiamin can also be transported into the cell and can be salvaged through several routes. In addition, two thiamin degrading enzymes have been characterized, one of which is linked to a novel salvage pathway.
登录
查看更多内容
影响因子：
14.8
作者：
Chatterjee, Abhishek;Li, Yue;Zhang, Yang;Grove, Tyler L.;Lee, Michael;Krebs, Carsten;Booker, Squire J.;Begley, Tadhg P.;Ealick, Steven E.
通讯作者：
Ealick, Steven E.
影响因子：
2.9
作者：
Arjunan, P;Nemeria, N;Furey, W
通讯作者：
Furey, W
影响因子：
5.7
作者：
Baker, LJ;Dorocke, JA;Timm, DE
通讯作者：
Timm, DE
影响因子：
14.8
作者：
Bettendorff, Lucien;Wirtzfeld, Barbara;Wins, Pierre
通讯作者：
Wins, Pierre
影响因子：
15
作者：
Chatterjee, Abhishek;Jurgenson, Christopher T.;Begley, Tadhg P.
通讯作者：
Begley, Tadhg P.