Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach.
Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach.
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光滑的液体注入多孔表面可防止微生物表面污染并杀死周围介质中的非粘附病原体：一种控制释放方法。
DOI：
10.1002/adfm.201505522
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发表时间：
2016-06-07
影响因子：
19
通讯作者：
Lynn DM
中科院分区：
文献类型：
--
作者：
Manna U;Raman N;Welsh MA;Zayas-Gonzalez YM;Blackwell HE;Palecek SP;Lynn DM
许多类型的光滑的液体注入多孔表面（或“SLIPS”）可以抵抗微生物的粘附和定殖。因此，这些“光滑”材料提供了新的方法，以防止在一系列商业和工业表面上结垢，包括生物医学设备。然而，虽然SLIPS可以防止它们所施加的表面上的污垢，但它们目前几乎不能防止非粘附性（粘附性）生物体的增殖，阻止它们定植在其他表面上，或防止它们参与可能导致感染和相关负担的其他行为。在这里，我们报告了一种设计多功能SLIPS的方法，该方法解决了这些问题，并扩展了抗微生物背景下光滑表面的潜在效用。我们的方法是基于小分子抗微生物剂从用于宿主输注的滑油相的多孔基质中的掺入和受控释放。我们证明了使用纳米多孔聚合物多层膜制造的SLIPS可以防止四种常见真菌和细菌病原体的短期和长期定植和生物膜形成（白色念珠菌、铜绿假单胞菌、大肠杆菌和金黄色葡萄球菌），并且组成这些材料的聚合物和油相可用于负载和维持三氯生的释放，三氯生是一种典型的疏水性和广谱抗菌剂，周边媒体。这种方法既改善了这些材料固有的防污性能，又赋予它们有效杀死寄生病原体的能力。最后，我们表明，这种方法可以用来制造双作用SLIPS复杂的表面上，包括管腔表面的柔性导管。这种策略有可能是一般的，我们预计，材料，策略和概念，在这里报告将使新的方法来设计光滑的表面，改善防污性能，并打开大门，新的应用程序的光滑的液体注入材料，主机或促进释放各种其他活性剂。我们报告了基于聚合物的光滑液体注入多孔表面（SLIPS），可以防止真菌和细菌病原体的粘附和定植，也可以杀死周围介质中的非粘附病原体。我们的方法利用这些光滑材料中的聚合物和液体油相来维持广谱抗菌剂的释放。这种受控释放方法改善了SLIPS的固有防污性能，具有通用范围的潜力，并在基础和应用背景下扩展了光滑、无污染表面的潜在效用。
Many types of slippery liquid-infused porous surfaces (or ‘SLIPS’) can resist adhesion and colonization by microorganisms. These ‘slippery’ materials thus offer new approaches to prevent fouling on a range of commercial and industrial surfaces, including biomedical devices. However, while SLIPS can prevent fouling on surfaces to which they are applied, they can currently do little to prevent the proliferation of non-adherent (planktonic) organisms, stop them from colonizing other surfaces, or prevent them from engaging in other behaviors that could lead to infection and associated burdens. Here, we report an approach to the design of multi-functional SLIPS that addresses these issues and expands the potential utility of slippery surfaces in antimicrobial contexts. Our approach is based on the incorporation and controlled release of small-molecule antimicrobial agents from the porous matrices used to host infused slippery oil phases. We demonstrate that SLIPS fabricated using nanoporous polymer multilayers can prevent short- and longer-term colonization and biofilm formation by four common fungal and bacterial pathogens (Candida albicans, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus), and that the polymer and oil phases comprising these materials can be exploited to load and sustain the release of triclosan, a model hydrophobic and broad-spectrum antimicrobial agent, into surrounding media. This approach both improves the inherent anti-fouling properties of these materials and endows them with the ability to efficiently kill planktonic pathogens. Finally, we show that this approach can be used to fabricate dual-action SLIPS on complex surfaces, including the luminal surfaces of flexible catheter tubes. This strategy has the potential to be general; we anticipate that the materials, strategies, and concepts reported here will enable new approaches to the design of slippery surfaces with improved anti-fouling properties and open the door to new applications of slippery liquid-infused materials that host or promote the release of a variety of other active agents. We report polymer-based slippery liquid-infused porous surfaces (SLIPS) that can prevent adhesion and colonization by fungal and bacterial pathogens and also kill non-adherent pathogens in surrounding media. Our approach exploits the polymer and liquid oil phases in these slippery materials to sustain the release of a broad-spectrum antimicrobial agent. This controlled release approach improves the inherent anti-fouling properties of SLIPS, has the potential to be general in scope, and expands the potential utility of slippery, non-fouling surfaces in both fundamental and applied contexts.
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