Understanding dengue virus evolution to support epidemic surveillance and counter-measure development.

Understanding dengue virus evolution to support epidemic surveillance and counter-measure development.
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了解登革热病毒的进化,以支持流行病监测和相对生长的发展。

DOI:
10.1016/j.meegid.2018.04.032
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发表时间:
2018-08
期刊:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
影响因子:
--
通讯作者:
Jarman RG
Jarman RG
中科院分区:
其他
文献类型:
--
作者:
Pollett S;Melendrez MC;Maljkovic Berry I;Duchêne S;Salje H;Cummings DAT;Jarman RG

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登革热病毒(DENV)造成了沉重的发病率和死亡率负担,并且由于四种不同的登革热病毒血清型在全球化、旅行、气候变化、城市化以及埃及伊蚊和白纹伊蚊媒介地理范围扩大的生态背景下共同传播,其全球负担正在上升。了解 DENV 进化为通过 RNA 病毒测序、生物信息学、系统发育和其他计算生物学方法的进步加强对 DENV 流行病的监测和应对提供了宝贵的机会。在这里,我们提供了 DENV 的进化和分子流行病学的范围概述,以及进化分析作为针对这种虫媒病毒病原体的公共卫生工具的一系列方法。
Dengue virus (DENV) causes a profound burden of morbidity and mortality, and its global burden is rising due to the co-circulation of four divergent DENV serotypes in the ecological context of globalization, travel, climate change, urbanization, and expansion of the geographic range of the Ae.aegypti and Ae.albopictus vectors. Understanding DENV evolution offers valuable opportunities to enhance surveillance and response to DENV epidemics via advances in RNA virus sequencing, bioinformatics, phylogenetic and other computational biology methods. Here we provide a scoping overview of the evolution and molecular epidemiology of DENV and the range of ways that evolutionary analyses can be applied as a public health tool against this arboviral pathogen.
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期刊: PLOS ONE
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