Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.
Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.
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DOI：
10.1002/ijc.30886
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发表时间：
2017-11-01
影响因子：
6.4
通讯作者：
Edefonti V
中科院分区：
文献类型：
--
作者：
Kawakita D;Lee YA;Turati F;Parpinel M;Decarli A;Serraino D;Matsuo K;Olshan AF;Zevallos JP;Winn DM;Moysich K;Zhang ZF;Morgenstern H;Levi F;Kelsey K;McClean M;Bosetti C;Garavello W;Schantz S;Yu GP;Boffetta P;Chuang SC;Hashibe M;Ferraroni M;La Vecchia C;Edefonti V
膳食纤维在头颈癌（HNC）病因学中的可能作用尚不清楚。我们使用来自国际头颈癌流行病学（INHANCE）联盟的10项病例对照研究（5959例病例和12,248例对照）的个体水平汇总数据，以检查纤维摄入量与口腔/咽喉癌之间的关联。采用无条件多元logistic回归对非酒精能量调整纤维摄入量的五分位数类别进行估计，并对烟草和酒精使用以及其他已知或推定的混杂因素进行调整。纤维摄入量与口腔癌和咽癌合并（第5个五分位数类别与第1个五分位数类别的OR = 0.49，95% CI：0.40-0.59;趋势p <0.001）和喉癌（OR = 0.66，95% CI：0.54-0.82，趋势p <0.001）呈负相关。然而，在口腔癌和咽癌合并的研究中，估计效果存在明显的异质性。尽管如此，对于口腔癌和咽癌的子位点以及在所考虑的协变量的大多数分层内，对于两个癌症位点，始终观察到负相关。我们的多中心大规模汇总分析结果表明，尽管存在研究间异质性，但更多的纤维摄入可能会降低HNC风险。
The possible role of dietary fiber in the etiology of head and neck cancers (HNCs) is unclear. We used individual-level pooled data from 10 case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders. Fiber intake was inversely associated with oral and pharyngeal cancer combined (OR for 5th vs. 1st quintile category = 0.49, 95% CI: 0.40-0.59; p for trend <0.001) and with laryngeal cancer (OR = 0.66, 95% CI: 0.54-0.82, p for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral and pharyngeal cancer combined. Nonetheless, inverse associations were consistently observed for the subsites of oral and pharyngeal cancers and within most strata of the considered covariates, for both cancer sites. Our findings from a multicenter large-scale pooled analysis suggest that, although in the presence of between-study heterogeneity, a greater intake of fiber may lower HNC risk.
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影响因子：
8.8
作者：
Bravi F;Bosetti C;Filomeno M;Levi F;Garavello W;Galimberti S;Negri E;La Vecchia C
通讯作者：
La Vecchia C
叶酸摄入量以及口腔和咽癌的风险：国际头颈癌流行病学联盟内的合并分析。
影响因子：
6.4
作者：
Galeone, Carlotta;Edefonti, Valeria;Parpinel, Maria;Leoncini, Emanuele;Matsuo, Keitaro;Talamini, Renato;Olshan, Andrew F;Zevallos, Jose P;Winn, Deborah M;Jayaprakash, Vijayvel;Moysich, Kirsten;Zhang, Zuo-Feng;Morgenstern, Hal;Levi, Fabio;Bosetti, Cristina;Kelsey, Karl;McClean, Michael;Schantz, Stimson;Yu, Guo-Pei;Boffetta, Paolo;Lee, Yuan-Chin Amy;Hashibe, Mia;La Vecchia, Carlo;Boccia, Stefania
通讯作者：
Boccia, Stefania
影响因子：
2.3
作者：
Divaris, Kimon;Olshan, Andrew F.;Smith, Joanna;Bell, Mary E.;Weissler, Mark C.;Funkhouser, William K.;Bradshaw, Patrick T.
通讯作者：
Bradshaw, Patrick T.
DOI：
10.1016/j.numecd.2015.05.005
发表时间：
2015-09-01
影响因子：
3.9
作者：
Augustin, L. S. A.;Kendall, C. W. C.;Poli, A.
通讯作者：
Poli, A.
影响因子：
2.9
作者：
FREUDENHEIM, JL;GRAHAM, S;WILKINSON, G
通讯作者：
WILKINSON, G