Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck Cancer Study.
Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck Cancer Study.
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DOI：
10.1007/s10552-009-9486-9
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发表时间：
2010-04
影响因子：
2.3
通讯作者：
Bradshaw, Patrick T.
中科院分区：
文献类型：
--
作者：
Divaris, Kimon;Olshan, Andrew F.;Smith, Joanna;Bell, Mary E.;Weissler, Mark C.;Funkhouser, William K.;Bradshaw, Patrick T.
关键词：
最近的报告将口腔健康和牙周病指标与头颈部鳞状细胞癌(SCCHN)风险增加联系起来。到目前为止，证据还不确定；我们的目标是在一项基于人群的大型研究的背景下，研究口腔健康和SCCHN风险之间的联系。卡罗莱纳州头颈癌研究是一项基于人群的病例对照研究，于2002-2006年在北卡罗来纳州的46个县进行。对照组(n=1,361)与病例(n=1,289)在年龄、种族和性别上频率匹配。口腔健康评估使用的访谈数据包括牙齿脱落和移动性、漱口水使用情况和就诊频率。受试者年龄26-80岁(中位年龄61岁)。对照组缺牙分布为0~5颗牙=60%，5~14颗牙=15%，16~28颗牙=25%。在控制协变量后，牙齿缺失与SCCHN没有任何显著的相关性(16-28对0-5颗牙齿：OR：1.21，95%CI：0.94，1.56)。自我报告的牙齿松动史与SCCHN风险增加有中等程度的关联(OR：1.33，95%CI：1.07，1.65)；然而，这种关联在从不吸烟的人中并不存在。常规牙科检查可降低30%的风险(OR：0.68，95%CI：0.53，0.87)。这些数据支持牙周病与SCCHN风险之间可能存在适度的关联，这是通过自我报告的牙齿丢失指标来衡量的，而不是牙齿丢失本身。
Recent reports have linked oral health and periodontal disease indicators with increased risk of squamous cell carcinoma of head and neck (SCCHN). Thus far, evidence has been inconclusive; our objective was to study the association between oral health and SCCHN risk in the context of a large population-based study. A population-based case–control study of incident SCCHN, the Carolina Head and Neck Cancer Study was carried out in 2002–2006 in 46 counties in North Carolina. Controls (n = 1,361) were frequency matched with cases (n = 1,289) on age, race, and gender. Oral health was assessed using interview data on tooth loss and mobility, mouthwash use, and frequency of dental visits. Subjects were 26–80 years old (median age = 61). The distribution of tooth loss among controls was 0–5 teeth = 60%; 5–14 = 15%; and 16–28 = 25%. After controlling for covariates, tooth loss did not yield any notable association with SCCHN (16–28 vs. 0–5 lost teeth: OR: 1.21, 95% CI: 0.94, 1.56). Self-reported history of tooth mobility was moderately associated with increased SCCHN risk (OR: 1.33, 95% CI: 1.07, 1.65); however, the association did not persist among never smokers. Routine dental visits were associated with 30% risk reduction (OR: 0.68, 95% CI: 0.53, 0.87). These data provide support for a possible modest association of periodontal disease, as measured by self-reported tooth loss indicators, but not tooth loss per se, with SCCHN risk.
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