Dual-Responsive Mesoporous Silica Nanoparticles Mediated Codelivery of Doxorubicin and Bcl-2 SiRNA for Targeted Treatment of Breast Cancer
Dual-Responsive Mesoporous Silica Nanoparticles Mediated Codelivery of Doxorubicin and Bcl-2 SiRNA for Targeted Treatment of Breast Cancer
复制标题
双响应介孔二氧化硅纳米颗粒介导的多柔比星和 Bcl-2 SiRNA 共递送用于乳腺癌的靶向治疗
DOI：
10.1021/acs.jpcc.6b06759
复制
发表时间：
2016-09
影响因子：
3.7
通讯作者：
He, Chuanglong
中科院分区：
文献类型：
--
作者：
Qin, Ming;Mo, Xiumei;Wang, Hongsheng;He, Chuanglong
化疗与基因治疗的联合应用可提高肿瘤的治疗效果。为了实现这一目标，开发了一种新的基于介孔二氧化硅纳米颗粒（MSNs）的共递送系统，用于靶向同时递送多柔比星（DOX）和Bcl-2小干扰RNA（siRNA）进入乳腺癌细胞。通过二硫键修饰聚乙烯亚胺-聚赖氨酸共聚物（PEI-PLL），并与叶酸连接的聚乙二醇（FA-PEG）偶联，制备了多功能MSNs（MSNs-PPPFA）。多功能MSNs-PPPFA纳米载体具有将DOX包封到MSNs的介孔通道中的能力，同时通过阳离子MSNs-PPPFA和阴离子siRNA之间的静电相互作用携带siRNA。所得的MSNs-PPPFA纳米颗粒用各种技术表征。药物释放结果表明，DOX从DOX-MSNs-PPPFA释放的pH和氧化还原都响应，和结果。
The combination of chemotherapy and gene therapy could induce the enhanced therapeutic efficacy in the cancer therapy. To achieve this goal, a new mesoporous silica nanoparticles (MSNs)-based codelivery system was developed for targeted simultaneous delivery of doxorubicin (DOX) and Bcl-2 small interfering RNA (siRNA) into breast cancer cells. The multifunctional MSNs (MSNs-PPPFA) were prepared by modification of polyethylenimine–polylysine copolymers (PEI-PLL) via the disulfide bonds, to which a targeting ligand folate-linked poly(ethylene glycol) (FA-PEG) was conjugated. The multifunctional MSNs-PPPFA nanocarrier has the ability to encapsulate DOX into the mesoporous channels of MSNs, while simultaneously carrying siRNA via electrostatic interaction between cationic MSNs-PPPFA and anionic siRNA. The resulting MSNs-PPPFA nanoparticles were characterized with various techniques. The drug release results reveal that DOX released from DOX-loaded MSNs-PPPFA are both pH- and redox-responsive, and the results ...
登录
查看更多内容
影响因子：
13.3
作者：
Chen, Alex M.;Zhang, Min;Wei, Dongguang;Stueber, Dirk;Taratula, Oleh;Minko, Tamara;He, Huixin
通讯作者：
He, Huixin
影响因子：
17.1
作者：
Meng H;Liong M;Xia T;Li Z;Ji Z;Zink JI;Nel AE
通讯作者：
Nel AE
影响因子：
14
作者：
Liu, Xin;Sun, Jiao
通讯作者：
Sun, Jiao
基于叶酸缀合 BSA 的 pH 敏感阿霉素前药，用于肿瘤靶向药物递送
影响因子：
14
作者：
Du, Changli;Deng, Dawei;Gu, Yueqing
通讯作者：
Gu, Yueqing
DOI：
10.1039/c5tb00304k
发表时间：
2015-07
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
M. Martínez-Carmona;A. Baeza;M. A. Rodriguez-Milla;J. García-Castro;M. Vallet‐Regí
通讯作者：
M. Martínez-Carmona;A. Baeza;M. A. Rodriguez-Milla;J. García-Castro;M. Vallet‐Regí