Depression and cognitive function in maintenance hemodialysis patients.
Depression and cognitive function in maintenance hemodialysis patients.
复制标题
DOI：
10.1053/j.ajkd.2010.04.018
复制
发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Sarnak MJ
中科院分区：
文献类型：
--
作者：
Agganis BT;Weiner DE;Giang LM;Scott T;Tighiouart H;Griffith JL;Sarnak MJ
抑郁症和认知障碍在血液透析患者中很常见，与不良的临床结果相关，并增加了医疗保健资源的负担。波士顿地区 241 名维持性血液透析患者的横断面队列 抑郁症状，定义为流行病学研究中心抑郁量表 (CES-D) 评分为 16 或更高 详细神经认知电池表现 平均年龄为 63.8 岁，49.0% 为女性，21.6% 为非裔美国人，中位透析持续时间为 13.8 个月。有 57 名（23.7%）参与者有明显的抑郁症状。在调整年龄、性别、教育程度和其他合并症的多变量分析中，有或没有抑郁症状的参与者在简易精神状态检查（p = 0.4）和记忆测试中表现相似。然而，抑郁症状较严重的参与者在评估处理速度、注意力和执行功能的测试中表现明显较差，包括路径制作测试 B (p=0.02) 和数字符号编码 (p=0.01)。使用 CES-D 评分≥18 来定义抑郁症并没有显着改变结果。横断面设计，缺乏脑成像 抑郁症状负担较重的血液透析患者在与处理速度和执行功能相关的认知测试中表现较差。需要进一步的研究来评估治疗抑郁症状对透析患者认知能力的影响。
Both depression and cognitive impairment are common in hemodialysis patients, are associated with adverse clinical outcomes, and place an increased burden on health care resources. Cross-sectional cohort 241 maintenance hemodialysis patients in the Boston area Depressive symptomatology, defined by a Center for Epidemiological Studies Depression Scale (CES-D) score of 16 or higher Performance on a detailed neurocognitive battery Mean age was 63.8 years, 49.0% were female, 21.6% were African American, and median dialysis duration was 13.8 months. There were 57 (23.7%) participants with significant depressive symptoms. In multivariable analysis adjusting for age, sex, education and other comorbid conditions, participants with and without depressive symptoms performed similarly on the Mini-Mental State Examination (p=0.4) and tests of memory. However, participants with greater depressive symptoms performed significantly worse on tests assessing processing speed, attention, and executive function, including Trails Making Test B (p=0.02) and Digit-Symbol Coding (p=0.01). Defining depression using a CES-D score ≥18 did not substantially change results. Cross-sectional design, absence of brain imaging Hemodialysis patients with a greater burden of depressive symptoms perform worse on tests of cognition related to processing speed and executive function. Further research is needed to assess the effects of treating depressive symptoms on cognitive performance in dialysis patients.
登录
查看更多内容
影响因子：
19.6
作者：
Cukor, Daniel;Rosenthal, Deborah S.;Kimmel, Paul L.
通讯作者：
Kimmel, Paul L.
影响因子：
2.8
作者：
Hayes TL;Larimer N;Adami A;Kaye JA
通讯作者：
Kaye JA
DOI：
10.2215/cjn.00030505
发表时间：
2006-05-01
影响因子：
9.8
作者：
Boulware, L. Ebony;Liu, Yongmei;Powe, Neil R.
通讯作者：
Powe, Neil R.
影响因子：
4
作者：
Bogner, Hillary R.;Bruce, Martha L.;Alexopoulos, George S.
通讯作者：
Alexopoulos, George S.
影响因子：
10.6
作者：
Alexopoulos, GS;Kiosses, DN;Gunning-Dixon, F
通讯作者：
Gunning-Dixon, F