The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study
The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study
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血浆同型半胱氨酸对膳食叶酸小幅增加的反应：一项初级保健研究
DOI：
10.1038/sj.ejcn.1600576
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发表时间：
1998
影响因子：
4.7
通讯作者：
A. Dowell
中科院分区：
文献类型：
--
作者：
C. Schorah;H. Devitt;M. Lucock;A. Dowell
目的：评估膳食叶酸对普通人群血浆同型半胱氨酸浓度的长期影响，同型半胱氨酸是闭塞性血管疾病的独立危险因素。设计：随机双盲安慰剂对照干预研究。研究对象：119名健康的志愿者，他们的强化叶酸或补充叶酸的摄入量很低，通过一封来自市中心一个大型全科诊所的病人登记簿的信被招募。方法：志愿者被随机分为两组，一组食用未经强化的谷物，另一组食用每份含有200 μg叶酸的强化谷物，另一组食用不含其他维生素的谷物。在补充前和治疗4、8和24周时采集血样，分析血浆同型半胱氨酸、半胱氨酸和维生素B12以及血清和红细胞叶酸。94名受试者完成了这项研究，在所有四种情况下都提供了血液样本。结果：在食用非强化谷物的人群中，任何测量参数都没有显著变化。总体而言，谷物叶酸强化导致血清叶酸（66%）和红细胞叶酸（24%）显著增加（P<0.001），血浆同型半胱氨酸（10%）显著降低（P<0.001）。维生素B12和半胱氨酸没有变化。同型半胱氨酸的下降一直持续到研究结束，并且主要出现在最初血浆同型半胱氨酸最高或血清叶酸最低的人群中。结论：如果发现同型半胱氨酸是闭塞性血管疾病的一个致病危险因素，那么在普通人群中强化含有生理水平叶酸的食物应该对该疾病的患病率有显著影响。赞助：我们感谢英国凯洛格公司的财政支持。
Objectives: To assess the long term effects of small increases in dietary folic acid on the concentration of plasma homocysteine, an independent risk factor for occlusive vascular disease, in a general population.Design: A randomized double-blind placebo-controlled intervention study.Subjects: One hundred and nineteen healthy volunteers, whose intake of fortified or supplemental folic acid was low, were recruited by letter from the patient register of a large inner-city group general practice.Methods: Volunteers were randomized to receive unfortified cereals, or cereals fortified with 200 μg of folic acid per portion, with or without other vitamins. Blood samples were taken presupplement and at 4, 8 and 24 weeks on treatment and analysed for plasma homocysteine, cysteine and vitamin B12 and serum and red cell folate. Ninety-four subjects completed the study providing blood samples on all four occasions.Results: There were no significant changes in any measured parameter in those eating unfortified cereals. Overall, folic acid fortification of cereals led to significant increases (P<0.001) in serum folate (66%), and red cell folate (24%), and a decrease in plasma homocysteine (10%; P<0.001). There were no changes in vitamin B12 or cysteine. The homocysteine decrease persisted until the end of the study and was primarily seen in those who initially had the highest plasma homocysteine or the lowest serum folate.Conclusions: If homocysteine is found to be a causative risk factor in occlusive vascular disease, food fortification with physiological levels of folic acid should have a significant impact on the prevalence of the disease in the general population.Sponsorship: We acknowledge, with thanks, financial support from the Kellogg Company of Great Britain.
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影响因子：
7.1
作者：
PANCHARUNITI, N;LEWIS, CA;ROSEMAN, JM
通讯作者：
ROSEMAN, JM
血浆同型半胱氨酸水平升高作为动脉粥样硬化危险因素的重要性。
DOI：
10.1016/0003-4975(94)90522-3
发表时间：
1994
期刊：
The Annals of thoracic surgery
影响因子：
--
作者：
Masser,PA;TaylorJr,LM;Porter,JM
通讯作者：
Porter,JM
DOI：
10.1001/jama.1992.03490070059042
发表时间：
1992-08
期刊：
JAMA
影响因子：
--
作者：
M. Stampfer;M. Malinow;W. Willett;L. Newcomer;B. Upson;D. Ullmann;P. Tishler;C. Hennekens
通讯作者：
M. Stampfer;M. Malinow;W. Willett;L. Newcomer;B. Upson;D. Ullmann;P. Tishler;C. Hennekens
影响因子：
9.3
作者：
D. Jacobsen;V. Gatautis;R. Green;K. Robinson;S. R. Savon;M. Secic;Ji Ji-Ji;Joanne M. Otto;
通讯作者：
D. Jacobsen;V. Gatautis;R. Green;K. Robinson;S. R. Savon;M. Secic;Ji Ji-Ji;Joanne M. Otto;
影响因子：
5
作者：
Verhoef, P;Stampfer, MJ;Willett, WC
通讯作者：
Willett, WC