Soluble interleukin-2 receptor combined with interleukin-8 is a powerful predictor of future adverse cardiovascular events in patients with acute myocardial infarction.
Soluble interleukin-2 receptor combined with interleukin-8 is a powerful predictor of future adverse cardiovascular events in patients with acute myocardial infarction.
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DOI：
10.3389/fcvm.2023.1110742
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发表时间：
2023
影响因子：
3.6
通讯作者：
Lv, Qianzhou
中科院分区：
文献类型：
--
作者：
Pan, Kunming;Xu, Chenqi;Chen, Can;Chen, Shuqing;Zhang, Yuqian;Ding, Xiaoqiang;Xu, Xialian;Lv, Qianzhou
关键词：
白介素2受体(sIL-2R)和白介素8在急性心肌梗死(MI)患者中的作用尚不清楚。我们的目标是评估心肌梗塞患者血清sIL-2R和IL-8对未来主要不良心血管事件(MACEs)的预测价值，并将它们与目前反映心肌炎症和损伤的生物标志物进行比较。这是一项前瞻性的单中心队列研究。检测血清IL-1、β、sIL-2R、IL-6、IL-8、IL-10水平。检测目前预测MACES的生物标志物水平，包括高敏C反应蛋白、心肌肌钙蛋白T和N末端脑利钠肽原。临床事件收集时间为1年，中位数为2.2年(长期)。24例患者(13.8%，24/173)在1年的随访期内发生了MACES，40例(23.1%，40/173)在长期随访期发生了MACES。在所研究的五种白细胞介素组中，只有sIL-2R和IL-8在1年或长期随访期间与终点独立相关。SIL-2R或IL-8水平升高(高于临界值)的患者在1年内(sIL-2R：HR 7.7，3.3-18.0，p <； 0.001；IL-8：HR 4.8，2.1-10.7，p <； 0.001)和长期(sIL-2R：HR 7.7，3.3-18.0，p <； 0.001；IL-8：HR 4.82.1-10.7，p <； 0.001)后续行动。受试者特征曲线分析显示，sIL-2R、IL-8、sIL-2R联合IL-8的曲线下面积分别为0.66(0.54~0.79，p = 0.011)、0.69(0.56~0.82，p <； 0.001)和0.720(0.59~0.85，p <； 0.001)。在现有的预测模型中加入sIL-2R和IL-8，显著提高了预测能力(p = 0.029)，促使正确分类比例增加了20.8%。血清sIL-2R和IL-8水平的升高与心肌梗死患者随访期间的急性心肌梗死显著相关，提示sIL-2R和IL-8联合检测可能是识别新心血管事件风险增加的有用生物标志物。IL-2和IL-8有望成为抗炎治疗的靶点。
Little is known about the role of interleukin (IL) in patients with acute myocardial infarction (MI), especially soluble IL-2 receptor (sIL-2R) and IL-8. We aim to evaluate, in MI patients, the predictive value of serum sIL-2R and IL-8 for future major adverse cardiovascular events (MACEs), and compare them with current biomarkers reflecting myocardial inflammation and injury. This was a prospective, single-center cohort study. We measured serum concentrations of IL-1β, sIL-2R, IL-6, IL-8 and IL-10. Levels of current biomarkers for predicting MACEs were measured, including high-sensitivity C reactive protein, cardiac troponin T and N-terminal pro-brain natriuretic peptide. Clinical events were collected during 1-year and a median of 2.2 years (long-term) follow-up. Twenty-four patients (13.8%, 24/173) experienced MACEs during 1-year follow-up and 40 patients (23.1%, 40/173) during long-term follow-up. Of the five interleukins studied, only sIL-2R and IL-8 were independently associated with endpoints during 1-year or long-term follow-up. Patients with high sIL-2R or IL-8 levels (higher than the cutoff value) had a significantly higher risk of MACEs during 1-year (sIL-2R: HR 7.7, 3.3–18.0, p < 0.001; IL-8: HR 4.8, 2.1–10.7, p < 0.001) and long-term (sIL-2R: HR 7.7, 3.3–18.0, p < 0.001; IL-8: HR 4.8, 2.1–10.7, p < 0.001) follow-up. Receiver operator characteristic curve analysis regarding predictive accuracy for MACEs during 1-year follow-up showed that the area under the curve for sIL-2R, IL-8, sIL-2R combined with IL-8 was 0.66 (0.54–0.79, p = 0.011), 0.69 (0.56–0.82, p < 0.001) and 0.720 (0.59–0.85, p < 0.001), whose predictive value were superior to that of current biomarkers. The addition of sIL-2R combined with IL-8 to the existing prediction model resulted in a significant improvement in predictive power (p = 0.029), prompting a 20.8% increase in the proportion of correct classifications. High serum sIL-2R combined with IL-8 levels was significantly associated with MACEs during follow-up in patients with MI, suggesting that sIL-2R combined with IL-8 may be a helpful biomarker for identifying the increased risk of new cardiovascular events. IL-2 and IL-8 would be promising therapeutic targets for anti-inflammatory therapy.
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影响因子：
5.6
作者：
Kao TW;Huang CC
通讯作者：
Huang CC
DOI：
10.1038/s41569-021-00589-2
发表时间：
2022-01
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Fernandez DM;Giannarelli C
通讯作者：
Giannarelli C
影响因子：
3.8
作者：
Bakhshi, Hooman;Varadarajan, Vinithra;Lima, Joao A. C.
通讯作者：
Lima, Joao A. C.
影响因子：
1.6
作者：
Guo S;Wu J;Zhou W;Liu X;Liu Y;Zhang J;Jia S;Li J;Wang H
通讯作者：
Wang H
影响因子：
39.3
作者：
Schömig, K;Busch, G;Ott, I
通讯作者：
Ott, I