Transient peripheral vestibular hypofunction measured with vestibular short-latency evoked potentials following noise exposure in rats.
Transient peripheral vestibular hypofunction measured with vestibular short-latency evoked potentials following noise exposure in rats.
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DOI：
10.1152/jn.00131.2021
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发表时间：
2021-11-01
影响因子：
2.5
通讯作者：
King WM
中科院分区：
文献类型：
--
作者：
Stewart CE;Bauer DS;Altschuler RA;King WM
暴露于120 dB声压级（SPL）带限噪声导致延迟的起始潜伏期和减少的前庭短潜伏期诱发电位（VsEP）反应。这些变化在噪声过度刺激后4周仍然存在。噪声性听力损失（NIHL）的程度和持续时间因噪声强度而异。本研究调查了噪声引起的外周前庭功能减退（NPVH）是否也会随着较低强度的噪声暴露而降低程度和/或持续时间。在本研究中，大鼠暴露于强度较低的噪声（110 dB SPL），但持续时间（6小时）和频率范围（500- 4，000 Hz）与先前研究中使用的相同。分别于噪声暴露后1、3、7、14、21、28天测定VsEP。与120 dB SPL噪声暴露相比，110 dB SPL噪声暴露产生的VsEP反应缺陷较小，62%（13/21）的动物在1周内完全恢复。这些发现表明，NPVH，VsEP反应的损失或衰减，需要提高刺激强度才能引起可测量的反应，与NIHL相似，即较低的声级产生较小或短暂的缺陷。这些结果表明，它将是重要的，以确定前庭功能减退的程度和持续时间为不同的噪声暴露条件及其对平衡的影响。 新&值得注意的是，这是第一项研究表明，暂时的噪音引起的外周前庭功能减退，在暴露于连续噪音后恢复。
Exposure to 120 dB sound pressure level (SPL) band-limited noise results in delayed onset latency and reduced vestibular short-latency evoked potential (VsEP) responses. These changes are still present 4 wk after noise overstimulation. Noise-induced hearing loss (NIHL) has been shown to vary in extent and duration based on the noise intensity. This study investigated whether noise-induced peripheral vestibular hypofunction (NPVH) would also decrease in extent and/or duration with less intense noise exposure. In the present study, rats were exposed to a less intense noise (110 dB SPL) but for the same duration (6 h) and frequency range (500–4,000 Hz) as used in previous studies. The VsEP was assessed 1, 3, 7, 14, 21, and 28 days after noise exposure. In contrast to 120 dB SPL noise exposure, the 110 dB SPL noise exposures produced smaller deficits in VsEP responses that fully recovered in 62% (13/21) of animals within 1 wk. These findings suggest that NPVH, a loss or attenuation of VsEP responses with a requirement for elevated stimulus intensity to elicit measurable responses, is similar to NIHL, that is, lower sound levels produce a smaller or transient deficit. These results show that it will be important to determine the extent and duration of vestibular hypofunction for different noise exposure conditions and their impact on balance. NEW & NOTEWORTHY This is the first study to show a temporary noise-induced peripheral vestibular hypofunction that recovers following exposure to continuous noise.
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DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC
DOI：
10.1097/mao.0000000000001071
发表时间：
2016-09
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
--
作者：
Ryan AF;Kujawa SG;Hammill T;Le Prell C;Kil J
通讯作者：
Kil J
DOI：
10.1001/archotol.134.10.1099
发表时间：
2008-10-01
影响因子：
--
作者：
Hsu, Wei-Chung;Wang, Jung-Der;Young, Yi-Ho
通讯作者：
Young, Yi-Ho
影响因子：
2.5
作者：
Stewart, C. E.;Bauer, D. S.;King, W. M.
通讯作者：
King, W. M.
影响因子：
2.8
作者：
Jones, Timothy A.;Jones, Sherri M.;Vijayakumar, Sarath;Brugeaud, Aurore;Bothwell, Marcella;Chabbert, Christian
通讯作者：
Chabbert, Christian