PBDE concentrations in women's serum and fecundability.
PBDE concentrations in women's serum and fecundability.
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DOI：
10.1289/ehp.0901450
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发表时间：
2010-05
影响因子：
10.4
通讯作者：
Eskenazi B
中科院分区：
文献类型：
--
作者：
Harley KG;Marks AR;Chevrier J;Bradman A;Sjödin A;Eskenazi B
多溴二苯醚 (PBDE) 阻燃剂的接触非常普遍，97% 的美国人都可检测到其含量。尽管多溴联苯醚与动物的生殖和荷尔蒙影响有关，但尚无人类研究探讨其与生育力的关系。本研究旨在确定妊娠期间收集的孕妇血清中 PBDE 浓度是否与妊娠时间和月经周期特征相关。居住在加利福尼亚州一个低收入、以墨西哥移民为主的社区的孕妇 (n = 223) 接受了采访，以确定她们需要多少个月才能怀孕。收集血样并分析 PBDE。 PBDE 浓度经过脂质调整和 log10 转换。分析仅限于在 > 75% 的人口中检测到的 PBDE 同系物（BDE 47、99、100、153）。使用针对离散时间修改的 Cox 比例风险模型来获得 PBDE 与妊娠时间之间关系的生育能力比值比 (fOR)。我们在 > 97% 的女性中检测到了所有四种同源物。 BDE 47、99、100、153 以及这四种同系物总和的增加都与怀孕时间延长有关。我们观察到 BDE-100 的 fOR 显着降低 [调整后的 fOR = 0.6； 95% 置信区间 (CI)，0.4–0.9]、BDE-153（调整后的 fOR = 0.5；95%CI，0.3–0.8）以及四种同源物的总和（调整后的 fOR = 0.7；95%CI，0.5–1.0）。 PBDE 与月经周期特征无关。我们发现女性的生育力显着下降与接触多溴二苯醚有关。需要未来的研究来复制和证实这一发现。
Exposure to polybrominated diphenyl ether (PBDE) flame retardants is widespread, with 97% of Americans having detectable levels. Although PBDEs have been associated with reproductive and hormonal effects in animals, no human studies have examined their association with fertility. This study was designed to determine whether maternal concentrations of PBDEs in serum collected during pregnancy are associated with time to pregnancy and menstrual cycle characteristics. Pregnant women (n = 223) living in a low-income, predominantly Mexican-immigrant community in California were interviewed to determine how many months they took to become pregnant. Blood samples were collected and analyzed for PBDEs. PBDE concentrations were lipid adjusted and log10 transformed. Analyses were limited to PBDE congeners detected in > 75% of the population (BDEs 47, 99, 100, 153). Cox proportional hazards models modified for discrete time were used to obtain fecundability odds ratios (fORs) for the association of PBDEs and time to pregnancy. We detected all four congeners in > 97% of women. Increasing levels of BDEs 47, 99, 100, 153 and the sum of these four congeners were all associated with longer time to pregnancy. We observed significantly reduced fORs for BDE-100 [adjusted fOR = 0.6; 95% confidence interval (CI), 0.4–0.9], BDE-153 (adjusted fOR = 0.5; 95% CI, 0.3–0.8), and the sum of the four congeners (adjusted fOR = 0.7; 95% CI, 0.5–1.0). PBDEs were not associated with menstrual cycle characteristics. We found significant decreases in fecundability associated with PBDE exposure in women. Future studies are needed to replicate and confirm this finding.
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DOI：
10.1016/0890-6238(88)90023-8
发表时间：
1988-01-01
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Baird, D D
通讯作者：
Baird, D D
影响因子：
4.5
作者：
FOWLES, JR;FAIRBROTHER, A;KERKVLIET, NI
通讯作者：
KERKVLIET, NI
影响因子：
8.8
作者：
Darnerud, Per Ola;Aune, Marie;Hallgren, Sara
通讯作者：
Hallgren, Sara
影响因子：
3.4
作者：
Branchi, I;Alleva, E;Costa, LG
通讯作者：
Costa, LG
影响因子：
3.8
作者：
Dufault, C;Poles, G;Driscoll, LL
通讯作者：
Driscoll, LL