Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the normative aging study.
Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the normative aging study.
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DOI：
10.1289/ehp.0901396
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发表时间：
2010-06
影响因子：
10.4
通讯作者：
Suh HH
中科院分区：
文献类型：
--
作者：
Baja ES;Schwartz JD;Wellenius GA;Coull BA;Zanobetti A;Vokonas PS;Suh HH
急性暴露于环境空气污染与心脏结局的急性变化有关，通常在暴露后几个小时内。我们研究了空气污染物对心率校正QT间期(QTC)的影响，QTC是心室复极的心电图标志，以及与氧化应激相关的参与者特征和遗传多态是否改变了这些关联。我们使用随机截距的混合效应模型对退伍军人事务标准老龄化研究(NAS)的580名男性进行了QTC的重复测量。我们用二次约束分布滞后模型来估计访问前10小时内环境空气污染物(包括空气动力学直径中的细颗粒物≤2.5μm、臭氧(O3)、黑碳(BC)、二氧化氮(NO2)、一氧化碳(CO)和二氧化硫(SO2)浓度)对QTc值的累积影响。我们对与氧化应激相关的基因多态进行了基因分型，并使用遗传易感性分数(GSS)方法分析了污染-易感性分数的交互作用。周围交通污染物浓度与QTC延长有关。在就诊前10小时内，BC的四分位数范围变化与QTc值增加相关[1.89ms变化；95%可信区间(CI)，−为0.16至3.93]。我们发现，在就诊前4小时发生IQR改变(2.54毫秒改变；95%可信区间，0.28-4.80)与QTC类似。我们发现IQR的QTc增加，NO2和CO的变化，但这种变化在统计学上并不显著。相反，我们发现QTC与PM2.5、SO2和O3之间没有关联。在肥胖、糖尿病、非吸烟者或GSSS较高的参与者中，QTC和BC之间的关联更强。与交通相关的污染物可能会增加糖尿病患者、肥胖者和不吸烟的老年人的QTC；与氧化应激相关的基因变异的数量增加了这种影响。
Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure. We examined the effects of air pollutants on heart-rate–corrected QT interval (QTc), an electrocardiographic marker of ventricular repolarization, and whether these associations were modified by participant characteristics and genetic polymorphisms related to oxidative stress. We studied repeated measurements of QTc on 580 men from the Veterans Affairs Normative Aging Study (NAS) using mixed-effects models with random intercepts. We fitted a quadratic constrained distributed lag model to estimate the cumulative effect on QTc of ambient air pollutants including fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5), ozone (O3), black carbon (BC), nitrogen dioxide (NO2), carbon monoxide (CO), and sulfur dioxide (SO2) concentrations during the 10 hr before the visit. We genotyped polymorphisms related to oxidative stress and analyzed pollution–susceptibility score interactions using the genetic susceptibility score (GSS) method. Ambient traffic pollutant concentrations were related to longer QTc. An interquartile range (IQR) change in BC cumulative during the 10 hr before the visit was associated with increased QTc [1.89 msec change; 95% confidence interval (CI), −0.16 to 3.93]. We found a similar association with QTc for an IQR change in 1-hr BC that occurred 4 hr before the visit (2.54 msec change; 95% CI, 0.28–4.80). We found increased QTc for IQR changes in NO2 and CO, but the change was statistically insignificant. In contrast, we found no association between QTc and PM2.5, SO2, and O3. The association between QTc and BC was stronger among participants who were obese, who had diabetes, who were nonsmokers, or who had higher GSSs. Traffic-related pollutants may increase QTc among persons with diabetes, persons who are obese, and nonsmoking elderly individuals; the number of genetic variants related to oxidative stress increases this effect.
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影响因子：
10.4
作者：
Gold DR;Litonjua AA;Zanobetti A;Coull BA;Schwartz J;MacCallum G;Verrier RL;Nearing BD;Canner MJ;Suh H;Stone PH
通讯作者：
Stone PH
DOI：
10.1080/10473289.1991.10466955
发表时间：
1991-12-01
影响因子：
2.7
作者：
CHAN, CC;SPENGLER, JD;LEFKOPOULOU, M
通讯作者：
LEFKOPOULOU, M
影响因子：
2.1
作者：
Lee, I-Ming;Tsai, Shang-Shyue;Yang, ChunYuh
通讯作者：
Yang, ChunYuh
影响因子：
10.4
作者：
Gurgueira SA;Lawrence J;Coull B;Murthy GG;González-Flecha B
通讯作者：
González-Flecha B
与短期接触交通颗粒和硫酸盐相关的死亡风险。
影响因子：
10.4
作者：
Maynard D;Coull BA;Gryparis A;Schwartz J
通讯作者：
Schwartz J