Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial.
Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial.
复制标题
褪黑素可改善特发性慢性入睡失眠儿童的健康状况和睡眠：一项随机安慰剂对照试验。
DOI：
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发表时间：
2003
影响因子：
13.3
通讯作者：
G. Kerkhof
中科院分区：
文献类型：
--
作者：
M. Smits;H. V. van Stel;K. B. van der Heijden;A. Meijer;A. Coenen;G. Kerkhof
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OBJECTIVE
To investigate the effect of melatonin treatment on health status and sleep in children with idiopathic sleep-onset insomnia.
METHOD
A randomized, double-blind, placebo-controlled trial was conducted in a Dutch sleep center, involving 62 children, 6 to 12 years of age, who suffered more than 1 year from idiopathic chronic sleep-onset insomnia. Patients received either 5 mg melatonin or placebo at 7 pm. The study consisted of a 1-week baseline period, followed by a 4-week treatment. Health status was measured with the RAND General Health Rating Index (RAND-GHRI) and Functional Status II (FS-II) questionnaires. Lights-off time, sleep onset, and wake-up time were recorded in a diary, and endogenous dim light melatonin onset was measured in saliva.
RESULTS
The total scores of the RAND-GHRI and FS-II improved significantly more during melatonin treatment compared to placebo. The magnitude of change was much higher in the melatonin group than in the placebo group, with standardized response means for the RAND-GHRI of 0.69 versus 0.07 and for the FS-II of 1.61 versus 0.64. Melatonin treatment also significantly advanced sleep onset by 57 minutes, sleep offset by 9 minutes, and melatonin onset by 82 minutes, and decreased sleep latency by 17 minutes. Lights-off time and total sleep time did not change.
CONCLUSIONS
Melatonin improves health status and advances the sleep-wake rhythm in children with idiopathic chronic sleep-onset insomnia.
影响因子：
2.8
作者：
LEWY, AJ;AHMED, S;SACK, RL
通讯作者：
SACK, RL
影响因子：
5.6
作者：
R. Chervin;K. Archbold;James E. Dillon;K. Pituch;P. Panahi;R. Dahl;C. Guilleminault
通讯作者：
R. Chervin;K. Archbold;James E. Dillon;K. Pituch;P. Panahi;R. Dahl;C. Guilleminault