The Paf1 Complex: A Keystone of Nuclear Regulation Operating at the Interface of Transcription and Chromatin.
The Paf1 Complex: A Keystone of Nuclear Regulation Operating at the Interface of Transcription and Chromatin.
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DOI：
10.1016/j.jmb.2021.166979
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发表时间：
2021-07-09
影响因子：
5.6
通讯作者：
Arndt KM
中科院分区：
文献类型：
--
作者：
Francette AM;Tripplehorn SA;Arndt KM
RNA聚合酶II对转录的调节与染色质结构的调节密切相关。核小体的拆卸、重组和修饰所需的大量蛋白质与Pol II相互作用，以帮助其移动并抵消其对染色质的破坏作用。高度保守的聚合酶相关因子1复合物Paf1C与Pol II一起旅行，并对转录延伸和染色质结构施加控制，同时广泛影响单细胞和多细胞真核生物中的转录组。最近的研究已经取得了令人兴奋的新的见解Paf1C调节转录延伸，表观遗传修饰和真核基因表达的转录后步骤的机制。重要的是，这些功能研究现在得到了高分辨率结构信息的广泛基础的支持，提供了Paf1C及其整合到更大的Pol II延伸复合物中的详细视图。作为在染色质和转录之间的界面上操作的全局调节因子，Paf1C的影响是广泛的，并且其影响反映到核调节的其他领域，包括基因组稳定性、端粒维持和DNA复制。
The regulation of transcription by RNA polymerase II is closely intertwined with the regulation of chromatin structure. A host of proteins required for the disassembly, reassembly, and modification of nucleosomes interacts with Pol II to aid its movement and counteract its disruptive effects on chromatin. The highly conserved Polymerase Associated Factor 1 Complex, Paf1C, travels with Pol II and exerts control over transcription elongation and chromatin structure, while broadly impacting the transcriptome in both single cell and multicellular eukaryotes. Recent studies have yielded exciting new insights into the mechanisms by which Paf1C regulates transcription elongation, epigenetic modifications, and post-transcriptional steps in eukaryotic gene expression. Importantly, these functional studies are now supported by an extensive foundation of high-resolution structural information, providing intimate views of Paf1C and its integration into the larger Pol II elongation complex. As a global regulatory factor operating at the interface between chromatin and transcription, the impact of Paf1C is broad and its influence reverberates into other domains of nuclear regulation, including genome stability, telomere maintenance, and DNA replication.
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影响因子：
64.5
作者：
Bai X;Kim J;Yang Z;Jurynec MJ;Akie TE;Lee J;LeBlanc J;Sessa A;Jiang H;DiBiase A;Zhou Y;Grunwald DJ;Lin S;Cantor AB;Orkin SH;Zon LI
通讯作者：
Zon LI
影响因子：
4.6
作者：
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Bhargava, Purnima
影响因子：
3.1
作者：
Betz, JL;Chang, M;Jaehning, JA
通讯作者：
Jaehning, JA
影响因子：
16.8
作者：
Burckin, T;Nagel, R;Ares, M
通讯作者：
Ares, M
影响因子：
16
作者：
Ahn, SH;Kim, M;Buratowski, S
通讯作者：
Buratowski, S