A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women.
A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women.
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DOI：
10.1186/s12885-018-4553-9
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发表时间：
2018-06-05
期刊：
影响因子：
3.8
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Deziel NC;Yi H;Stapleton HM;Huang H;Zhao N;Zhang Y
越来越多的证据表明，接触有机磷酸盐阻燃剂（PFR）是普遍的，这些化学物质可以改变甲状腺激素的调节和功能。我们研究了PFR暴露与甲状腺癌之间的关系，以及个体或时间因素是否能预测PFR暴露。我们分析了2010-2013年收集的来自康涅狄格州甲状腺癌病例对照研究的100例女性乳头状甲状腺癌病例和100例女性对照的访谈数据和现场尿样。我们用质谱法测定了六种PFR代谢物的尿浓度。我们估计了单个和总计代谢物浓度的连续和类别（低、中、高）的比值比（OR）和95%置信区间（95% CI），并针对潜在的混杂因素进行了调整。我们使用多元线性回归分析研究了PFR代谢物浓度与个体特征（年龄、吸烟状况、饮酒量、体重指数[BMI]、收入、教育程度）和时间因素（季节、年份）之间的关系。无PFR与乳头状甲状腺癌风险显著相关。当按微小癌（肿瘤直径≤ 1 cm）和较大肿瘤（> 1 cm）分层时，结果仍然为空。我们观察到随着BMI的增加和在夏季，尿PFR浓度更高。在诊断时测量的尿PFR浓度与甲状腺癌风险增加无关。在更大的人群中进行调查或重复的诊断前尿生物标志物测量将为PFR暴露与甲状腺癌风险之间的关系提供更多的见解。本文的在线版本（10.1186/s12885-018-4553-9）包含补充材料，可供授权用户使用。
Growing evidence demonstrates that exposure to organophosphate flame retardants (PFRs) is widespread and that these chemicals can alter thyroid hormone regulation and function. We investigated the relationship between PFR exposure and thyroid cancer and whether individual or temporal factors predict PFR exposure. We analyzed interview data and spot urine samples collected in 2010–2013 from 100 incident female, papillary thyroid cancer cases and 100 female controls of a Connecticut-based thyroid cancer case-control study. We measured urinary concentrations of six PFR metabolites with mass spectrometry. We estimated odds ratios (OR) and 95% confidence intervals (95% CI) for continuous and categories (low, medium, high) of concentrations of individual and summed metabolites, adjusting for potential confounders. We examined relationships between concentrations of PFR metabolites and individual characteristics (age, smoking status, alcohol consumption, body mass index [BMI], income, education) and temporal factors (season, year) using multiple linear regression analysis. No PFRs were significantly associated with papillary thyroid cancer risk. Results remained null when stratified by microcarcinomas (tumor diameter ≤ 1 cm) and larger tumor sizes (> 1 cm). We observed higher urinary PFR concentrations with increasing BMI and in the summer season. Urinary PFR concentrations, measured at time of diagnosis, are not linked to increased risk of thyroid cancer. Investigations in a larger population or with repeated pre-diagnosis urinary biomarker measurements would provide additional insights into the relationship between PFR exposure and thyroid cancer risk. The online version of this article (10.1186/s12885-018-4553-9) contains supplementary material, which is available to authorized users.
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影响因子：
8.8
作者：
Ballesteros-Gomez, A.;Brandsma, S. H.;Leonards, P. E. G.
通讯作者：
Leonards, P. E. G.
影响因子：
11.8
作者：
Hoffman, Kate;Daniels, Julie L.;Stapleton, Heather M.
通讯作者：
Stapleton, Heather M.
影响因子：
3.5
作者：
Hill, Katie L.;Hamers, Timo;Letcher, Robert J.
通讯作者：
Letcher, Robert J.
影响因子：
11.8
作者：
Hoffman, Kate;Lorenzo, Amelia;Butt, Craig M.;Adair, Linda;Herring, Amy H.;Stapleton, Heather M.;Daniels, Julie L.
通讯作者：
Daniels, Julie L.
DOI：
10.1158/1055-9965.epi-08-0960
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Enewold L;Zhu K;Ron E;Marrogi AJ;Stojadinovic A;Peoples GE;Devesa SS
通讯作者：
Devesa SS