Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study.
Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study.
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DOI：
10.1016/j.atherosclerosis.2018.03.035
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发表时间：
2018-06
期刊：
影响因子：
5.3
通讯作者：
SESSA Research Group
中科院分区：
文献类型：
--
作者：
Hisamatsu T;Miura K;Fujiyoshi A;Kadota A;Miyagawa N;Satoh A;Zaid M;Yamamoto T;Horie M;Ueshima H;SESSA Research Group
钙化性主动脉瓣疾病（CAVD）是最常见的瓣膜疾病。尽管已知微量营养素会导致心血管疾病，但其与CAVD的关系仍缺乏评估。我们研究了血清镁、磷和钙水平与主动脉瓣钙化（AVC）的患病率、发生率和进展的关系。我们对年龄在40-79岁的日本男性进行了一项基于人群的前瞻性研究，基线时没有已知的心血管疾病和慢性肾脏疾病，并使用Agatston方法从连续计算机断层扫描图像中量化AVC。在基线时的938名参与者（平均年龄，63.7±9.9岁）中，173名（18.4%）观察到AVC患病率。在596例随访时无基线AVC的受试者中（中位持续时间为5.1年），138例（23.2%）观察到AVC发生率。在调整人口统计学、行为和心血管危险因素后，血清镁、磷和钙的最高与最低类别（95%置信区间）分别为0.62（0.44-0.86）、1.45（1.02-2.04）、1.43（0.95-2.15）;（0.62 -0.92）、1.93（1.28-2.91）、1.09（0.77-1.55）。血清镁、磷的线性趋势也均有统计学意义。在131名基线AVC的参与者中，任何血清微量营养素与AVC进展无关。血清镁与AVC患病率和发病率呈负相关，而血清磷与AVC患病率和发病率呈正相关，表明这些血清微量营养素可能是预测或预防CAVD的潜在候选者，并需要进一步研究。
Calcific aortic valve disease (CAVD) is the most common valve disease. Although micronutrients are known to contribute to cardiovascular disease, the relationship with CAVD remains poorly evaluated. We examined the association of serum levels of magnesium, phosphorus, and calcium with prevalence, incidence, and progression of aortic valve calcification (AVC). We conducted a prospective study in a population-based sample of Japanese men aged 40–79 years without known cardiovascular disease and chronic kidney disease at baseline, and quantified AVC from serial computed tomographic images with the Agatston method. Of 938 participants at baseline (mean age, 63.7±9.9 years), AVC prevalence was observed in 173 (18.4%). Of 596 participants without baseline AVC at follow-up (median duration, 5.1 years), AVC incidence was observed in 138 (23.2%). After adjustment for demographics, behaviors and cardiovascular risk factors, relative risks (95% confidence intervals) in the highest versus lowest categories of serum magnesium, phosphorus, and calcium were 0.62 (0.44–0.86), 1.45 (1.02–2.04), and 1.43 (0.95–2.15), respectively, for AVC prevalence and 0.62 (0.42–0.92), 1.93 (1.28–2.91), and 1.09 (0.77–1.55), respectively, for AVC incidence. Their linear trends of serum magnesium and phosphorus were also all statistically significant. Of 131 participants with baseline AVC, there was no association of any serum micronutrients with AVC progression. Serum magnesium was inversely associated, while serum phosphorus was positively associated, with AVC prevalence and incidence, suggesting that these serum micronutrients may be potential candidates for risk prediction or prevention of CAVD, and warranting further studies.
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影响因子：
4.8
作者：
Foley, Robert N.;Collins, Allan J.;Kalra, Philip A.
通讯作者：
Kalra, Philip A.
血清磷酸盐水平与主动脉瓣硬化和环形钙化的关联：心血管健康研究。
影响因子：
24
作者：
Linefsky, Jason P.;O'Brien, Kevin D.;Katz, Ronit;de Boer, Ian H.;Barasch, Eddy;Jenny, Nancy S.;Siscovick, David S.;Kestenbaum, Bryan
通讯作者：
Kestenbaum, Bryan
影响因子：
2.8
作者：
Owens, David S.;Katz, Ronit;Takasu, Junichiro;Kronmal, Richard;Budoff, Matthew J.;O'Brien, Kevin D.
通讯作者：
O'Brien, Kevin D.
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R
影响因子：
3.6
作者：
Arnaud, Maurice J.
通讯作者：
Arnaud, Maurice J.