Association between hair cortisol and diurnal basal cortisol levels: A 30-day validation study
Association between hair cortisol and diurnal basal cortisol levels: A 30-day validation study
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头发皮质醇与每日基础皮质醇水平之间的关联：一项为期 30 天的验证研究
DOI：
10.1016/j.psyneuen.2020.104650
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发表时间：
2020
影响因子：
3.7
通讯作者：
Nomura S
中科院分区：
文献类型：
--
作者：
Sugaya N;Izawa S;Ogawa N;Shirotsuki K;Nomura S
这项研究旨在验证毛发皮质醇与30天唾液皮质醇水平之间的关系。此外，毛发皮质醇的个体内稳定性以及毛发皮质醇与唾液皮质醇在几个时间域的关系也被系统地探讨了。24名成年人（男性15名，女性9名，平均年龄22.7±2.8岁）被要求在30天内每天采集3份唾液样本，分别在醒来后（时间1）、醒来后30分钟（时间2）和睡前（时间3）采集。在30天的研究期结束时，从尽可能靠近头皮的后顶点采集头发样本。基于第1次和第3次的曲线下面积显示，最靠近头皮的1 cm头发段的皮质醇水平与30天唾液皮质醇水平中度相关（r= 0.41,p= 0.047）。然而，在不同时间域的皮质醇觉醒反应、日斜率或其他指标中，没有观察到这种相关性。第3时刻唾液皮质醇均值与毛发皮质醇呈显著相关（r= 0.42,p= 0.041）。毛发皮质醇的个体内稳定性维持了至少4个月。毛发皮质醇在较长时间内（超过1个月或至少4个月）更能反映基础皮质醇水平，因此反映的是纵向皮质醇生成，而不是日常的时间皮质醇反应。唾液皮质醇是短期或日常压力反应的理想指标。研究人员应根据研究目标选择合适的指标，如毛发皮质醇作为基础水平（或特征）或唾液皮质醇作为反应（或状态）。
This study aimed to validate the association between hair cortisol and 30-day integrated salivary cortisol levels. Additionally, the intra-individual stability of the hair cortisol and the association between hair cortisol and salivary cortisol in several time domains were systematically explored. Twenty-four adults (15 men and 9 women, mean age: 22.7 ± 2.8 years) were asked to collect three saliva samples per day for 30 days, immediately after awakening (time 1), 30 min after awakening (time 2), and at bedtime (time 3). The hair sample was taken from the posterior vertex as close as possible to the scalp at the end of the 30-day study period. The area under the curve based on times 1 and 3 showed that cortisol levels in the 1 cm hair segment closest to the scalp were moderately correlated with the 30-day salivary cortisol levels (r= 0.41,p= 0.047). However, this correlation was not observed for the cortisol awakening response, diurnal slope, or other metrics in different time domains. The mean salivary cortisol at time 3 was significantly correlated with hair cortisol (r= 0.42,p= 0.041). Intra-individual stability of the hair cortisol was maintained for at least 4 months. Hair cortisol may reflect basal cortisol levels more substantially over longer periods (longer than 1 month and for at least 4 month), thus reflecting longitudinal cortisol production, rather than the day-to-day temporal cortisol response. Salivary cortisol is an ideal metric for short-term or day-to-day stress response. Researchers should select suitable metrics, such as hair cortisol for basal level (or trait) or salivary cortisol for response (or state), depending on the study objective.
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DOI：
--
发表时间：
2018
期刊：
Life Science
影响因子：
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