Risk and protective factors associated with BV chronicity among women in Rakai, Uganda.
Risk and protective factors associated with BV chronicity among women in Rakai, Uganda.
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DOI：
10.1136/sextrans-2019-054145
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发表时间：
2020-08
影响因子：
3.6
通讯作者：
Wawer MJ
中科院分区：
文献类型：
--
作者：
Thoma ME;Brotman RM;Gray RH;Sewankambo NK;Wawer MJ
To assess risk and protective factors associated with bacterial vaginosis (BV) chronicity ascertained by Nugent score criteria. A longitudinal cohort study included 255 sexually experienced, postmenarcheal women who provided weekly self-collected vaginal swabs for up to 2 years. Vaginal swabs were scored using Nugent criteria and classified as normal (≤3), intermediate (4–6) and Nugent-BV (≥7). Detailed behavioural/health information were assessed every 6 months. A per-woman longitudinal summary measure of BV chronicity was defined as the percentage of each woman’s weekly vaginal assessments scored as Nugent-BV over a 6-month interval. Risk and protective factors associated with BV chronicity were assessed using multiple linear regression with generalised estimating equations. Average BV chronicity was 39% across all follow-up periods. After adjustment, factors associated with BV chronicity included baseline Nugent-BV (β=35.3, 95% CI 28.6 to 42.0) compared with normal baseline Nugent scores and use of unprotected water for bathing (ie, rainwater, pond, lake/stream) (β=12.0, 95% CI 3.4 to 20.5) compared with protected water sources (ie, well, tap, borehole). Women had fewer BV occurrences if they were currently pregnant (β=−6.6, 95% CI −12.1 to 1.1), reported consistent condom use (β=−7.7, 95% CI −14.2 to 1.3) or their partner was circumcised (β=−5.8, 95% CI −11.3 to 0.3). Factors associated with higher and lower values of BV chronicity were multifactorial. Notably, higher values of BV chronicity were associated with potentially contaminated bathing water. Future studies should examine the role of waterborne microbial agents in the pathogenesis of BV.
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影响因子：
17.1
作者：
Gajer P;Brotman RM;Bai G;Sakamoto J;Schütte UM;Zhong X;Koenig SS;Fu L;Ma ZS;Zhou X;Abdo Z;Forney LJ;Ravel J
通讯作者：
Ravel J
影响因子：
3.7
作者：
Bilardi, Jade E.;Walker, Sandra;Bradshaw, Catriona
通讯作者：
Bradshaw, Catriona
影响因子：
9.8
作者：
Gray, Ronald H.;Kigozi, Godfrey;Serwadda, David;Makumbi, Frederick;Nalugoda, Fred;Watya, Stephen;Moulton, Laurence;Chen, Michael Z.;Sewankambo, Nelson K.;Kiwanuka, Noah;Sempijja, Victor;Lutalo, Tom;Kagayii, Joseph;Wabwire-Mangen, Fred;Ridzon, Renee;Bacon, Melanie;Wawer, Maria J.
通讯作者：
Wawer, Maria J.
影响因子：
--
作者：
Amenu, Kebede;Shitu, Desalew;Abera, Mesele
通讯作者：
Abera, Mesele
DOI：
10.1111/tmi.12334
发表时间：
2014-08
期刊：
Tropical medicine & international health : TM & IH
影响因子：
--
作者：
Bain R;Cronk R;Hossain R;Bonjour S;Onda K;Wright J;Yang H;Slaymaker T;Hunter P;Prüss-Ustün A;Bartram J
通讯作者：
Bartram J