Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications.
Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications.
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脓毒症中的树突状细胞：病理改变和治疗意义
DOI：
10.1155/2017/3591248
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发表时间：
2017
影响因子：
4.1
通讯作者：
Ji XY
中科院分区：
文献类型：
--
作者：
Wu DD;Li T;Ji XY
近年来，脓毒症是危重病人的主要死亡原因。树突状细胞(DC)是重要的抗原提呈细胞，通过调节先天免疫和获得性免疫，在免疫应答中发挥关键作用。在脓毒症的发展过程中，DC的数量、单核细胞向DC的分化以及与DC功能相关的表面分子水平都会发生变化。脓毒症时树突状细胞的改变涉及多种机制，包括诱导细胞凋亡、产生活性氧、激活Wnt信号通路、表观遗传调控以及Toll样受体依赖信号的变化。本文综述了脓毒症中DC亚群的分类及其参与DC改变的机制，并进一步讨论了针对脓毒症中DC的治疗策略，以改善脓毒症进展过程中的异常免疫反应，延长生命。
Sepsis is the leading cause of death for critically ill patients in recent years. Dendritic cells (DCs) are important antigen-presenting cells and play a key role in immune response by regulating the innate and adaptive immunity. The number of DCs, the differentiation of monocytes into DCs, and the levels of surface molecules associated with the function of DCs are changed in the development of sepsis. There are many mechanisms involved in the alterations of DCs during sepsis, including the induction of apoptosis, reactive oxygen species generation, activation of the Wnt signaling pathway, epigenetic regulation, and variation in Toll-like receptor-dependent signaling. In this review, we present the classifications of DC subsets and mechanisms involved in the alterations of DCs in sepsis, as well as further discuss the therapeutic strategies targeting DCs in sepsis to improve the aberrant immune response and prolong the life during sepsis progression.
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影响因子：
3.4
作者：
Dennis KL;Blatner NR;Gounari F;Khazaie K
通讯作者：
Khazaie K
影响因子：
4.6
作者：
Faivre, V.;Lukaszewicz, A. -C.;Haziot, A.
通讯作者：
Haziot, A.
影响因子：
3.7
作者：
Bergenfelz, C.;Janols, H.;Leandersson, K.
通讯作者：
Leandersson, K.
影响因子：
5.2
作者：
Fink MP
通讯作者：
Fink MP
影响因子：
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作者：
Fan X;Liu Z;Jin H;Yan J;Liang HP
通讯作者：
Liang HP