Enhanced in vivo delivery of 5-fluorouracil by ethosomal gels in rabbit ear hypertrophic scar model.
Enhanced in vivo delivery of 5-fluorouracil by ethosomal gels in rabbit ear hypertrophic scar model.
复制标题
醇体凝胶在兔耳肥厚性疤痕模型中增强 5-氟尿嘧啶的体内递送
DOI：
10.3390/ijms151222786
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发表时间：
2014-12-09
影响因子：
5.6
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Wo Y;Zhang Z;Zhang Y;Zhang Z;Wang K;Mao X;Su W;Li K;Cui D;Chen J
由于溶酶体凝胶具有良好的水溶性和生物相容性，其在经皮给药系统中的应用引起了人们极大的兴趣。然而，目前还没有明确的描述将EGs作为增生性疤痕治疗的载体。本文成功制备了一种新型负载5-氟尿嘧啶的透皮EGs （5-FU EGs）并对其进行了表征。体外稳定性实验表明，4±1℃条件下保存30 d的5-FU鸡蛋比25±1℃条件下保存30 d的5-FU鸡蛋具有更好的尺寸稳定性。此外，在共聚焦激光扫描显微镜下，罗丹明6g标记的EGs在24 h内渗透到兔耳增生性瘢痕的真皮深处，表明EGs是通过瘢痕组织的可选递送载体。此外，5-FU鸡蛋组在兔耳瘢痕模型中的疤痕升高指数（Scar Elevation Index， SEI）低于5-FU磷酸盐缓冲盐水凝胶组和对照组。综上所述，这些结果表明，负载5-氟尿嘧啶的卵细胞递送系统是未来肥厚性疤痕治疗的理想候选药物。
Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. However, there has not been an explicit description of applying EGs as a vehicle for hypertrophic scars treatment. Here, a novel transdermal EGs loaded with 5-fluorouracil (5-FU EGs) was successfully prepared and characterized. The stability assay in vitro revealed that 5-FU EGs stored for a period of 30 days at 4 ± 1 °C had a better size stability than that at 25 ± 1 °C. Furthermore, using confocal laser scanning microscopy, EGs labeled with Rhodamine 6 G penetrated into the deep dermis of the hypertrophic scar within 24 h in the rabbit ear hypertrophic model suggested that the EGs were an optional delivery carrier through scar tissues. In addition, the value of the Scar Elevation Index (SEI) of 5-FU EGs group in the rabbit ear scar model was lower than that of 5-FU Phosphate Buffered Saline gel and Control groups. To conclude, these results suggest that EGs delivery system loaded 5-fluorouracil is a perfect candidate drug for hypertrophic scars therapy in future.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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