Intestinal microbial circadian rhythms drive sex differences in host immunity and metabolism.
Intestinal microbial circadian rhythms drive sex differences in host immunity and metabolism.
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DOI：
10.1016/j.isci.2023.107999
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发表时间：
2023-10-20
期刊：
影响因子：
5.8
通讯作者：
Jasarevic, Eldin
中科院分区：
文献类型：
--
作者：
Munyoki, Sarah K.;Goff, Julie P.;Kolobaric, Antonija;Long, Armari;Mullett, Steven J.;Burns, Jennifer K.;Jenkins, Aaron K.;DePoy, Lauren;Wendell, Stacy G.;McClung, Colleen A.;Morrison, Kathleen E.;Jasarevic, Eldin
昼夜节律动态地调节新陈代谢和免疫方面的性别差异，而昼夜节律紊乱增加了代谢紊乱的风险。我们利用无菌和常规化的小鼠，以及饮食衍生的脂肪、纤维和微生物区系可获得的碳水化合物的处理，研究了特定性别肠道微生物昼夜节律在宿主代谢中的作用。我们的发现表明，参与免疫和新陈代谢的基因昼夜节律的性别差异取决于微生物区系的振荡、微生物代谢功能和微生物代谢产物。此外，我们发现，食用肥胖、高脂肪、低纤维饮食会导致微生物区系、代谢物和宿主基因表达的昼夜节律发生性别特有的变化，这与代谢功能障碍的严重程度的性别差异有关。我们的结果表明，微生物昼夜节律有助于免疫和新陈代谢的性别差异，饮食因素可以带来新的昼夜节律，并改变宿主-微生物昼夜节律动力学中的性别差异的大小。肠道微生物昼夜节律因性别不同宿主转录网络中的性别特有节律依赖微生物组饮食诱导肥胖携带新的性别特有微生物和宿主基因昼夜节律数据收集的时间影响性别差异的大小人类代谢；微生物学；微生物组
Circadian rhythms dynamically regulate sex differences in metabolism and immunity, and circadian disruption increases the risk of metabolic disorders. We investigated the role of sex-specific intestinal microbial circadian rhythms in host metabolism using germ-free and conventionalized mice and manipulation of dietary-derived fat, fiber, and microbiota-accessible carbohydrates. Our findings demonstrate that sex differences in circadian rhythms of genes involved in immunity and metabolism depend on oscillations in microbiota, microbial metabolic functions, and microbial metabolites. Further, we show that consuming an obesogenic, high-fat, low-fiber diet produced sex-specific changes in circadian rhythms in microbiota, metabolites, and host gene expression, which were linked to sex differences in the severity of metabolic dysfunction. Our results reveal that microbial circadian rhythms contribute to sex differences in immunity and metabolism and that dietary factors can entrain new circadian rhythms and modify the magnitude of sex differences in host-microbe circadian dynamics. Intestinal microbial circadian rhythms differ by sex Sex-specific rhythms in host transcriptional networks are microbiome-dependent Diet-induced obesity entrains new sex-specific microbial and host gene circadian rhythms Timing of data collection influences the magnitude of sex differences Human metabolism; Microbiology; Microbiome
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
对C57BL/6J小鼠的饮食脂肪操纵的反应表型性二态性。
影响因子：
3
作者：
Casimiro I;Stull ND;Tersey SA;Mirmira RG
通讯作者：
Mirmira RG
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
6.5
作者：
COLE, LC
通讯作者：
COLE, LC
DOI：
10.1152/ajpgi.00172.2015
发表时间：
2015-10-01
期刊：
American journal of physiology. Gastrointestinal and liver physiology
影响因子：
--
作者：
Chassaing B;Miles-Brown J;Pellizzon M;Ulman E;Ricci M;Zhang L;Patterson AD;Vijay-Kumar M;Gewirtz AT
通讯作者：
Gewirtz AT