Quantifying the impact of underlying measurement error on cervical spinal cord diffusion tensor imaging at 3T.

Quantifying the impact of underlying measurement error on cervical spinal cord diffusion tensor imaging at 3T.
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DOI:
10.1002/jmri.25308
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发表时间:
2016-12
影响因子:
4.4
通讯作者:
Smith, Seth A.
Smith, Seth A.
中科院分区:
医学2区
文献类型:
--
作者:
By, Samantha;Smith, Alex K.;Dethrage, Lindsey M.;Lyttle, Bailey D.;Landman, Bennett A.;Creasy, Jeffrey L.;Pawate, Siddharama;Smith, Seth A.

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旨在以临床相关扫描时间当量(STE)经验性地表征和量化梯度加权方案对人体脊髓扩散张量成像的外观和保真度的影响。在3特斯拉的5个健康对照中,我们评估了重测重复性,并对DTI衍生指数进行了体素分析(各向异性分数(FA)、平均(MD)、轴向(AD)和径向(RD)扩散率),以评估测量误差的空间依赖性和三种不同采样方案的差异(6、15和32方向),STE为4.5、9和18分钟。还进行了主观评估。在6个方向上,柱特异性误差最高(FA在背柱、侧柱和灰质中的效应量分别为2.9%、4.4%和7.2%),并且与15个方向方案不同(p<0.05)。15个方向和32个方向的STE序列的误差差异较小(p>0.05)。对于FA和AD,测量误差在灰质中普遍存在,而CSF的部分容积效应严重影响RD。测量误差随着扫描时间的增加而减少(p<0.01),尽管扫描时间超过9分钟时收益递减(p<0.05)。9分钟的15个方向的方案产生的颈脊髓的测量误差低。
To empirically characterize and quantify the impact of gradient weighting schemes on the appearance and fidelity of diffusion tensor imaging of the human spinal cord in vivo in clinically relevant scan time equivalents (STE). In five healthy controls at 3 tesla, we evaluated test-retest reproducibility and performed voxel-wise analysis of DTI-derived indices (fractional anisotropy (FA), mean (MD), axial (AD) and radial (RD) diffusivity) in the cervical spinal cord to assess spatial dependencies of measurement error and differences across three different sampling schemes (6, 15, and 32 directions) at STE of 4.5, 9 and 18 minutes. A subjective assessment was also performed. With six directions, column-specific errors are highest (effect size=2.9%, 4.4%, 7.2% for FA in dorsal column, lateral column, and gray matter) and different than the 15-direction scheme (p<0.05). STE sequences with 15 and 32 directions exhibited small differences in error (p>0.05). For FA and AD, measurement errors are prevalent in gray matter, while partial volume effects with CSF heavily influence RD. Measurement errors decreased with increasing scan time (p<0.01), albeit with diminishing returns at scan times longer than 9 minutes (p<0.05). A 15-direction scheme of 9 minutes yields measurements of the cervical spinal cord with low error.
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