Central gain control in tinnitus and hyperacusis.
Central gain control in tinnitus and hyperacusis.
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DOI：
10.3389/fneur.2014.00206
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发表时间：
2014
影响因子：
3.4
通讯作者：
Salvi RJ
中科院分区：
文献类型：
--
作者：
Auerbach BD;Rodrigues PV;Salvi RJ
噪声或耳毒性药物暴露所致的感音神经性听力损失降低了从耳蜗传向中枢听觉系统的神经活动。尽管耳蜗输出减少，但在阈值以上的强度下，来自更中央听觉结构的神经活动却矛盾地增强。由于感觉输入的丧失，中枢听觉活动的补偿性增加被称为中枢增益增强。中枢增益增强被认为是导致听觉过敏症和耳鸣的潜在机制，这两种令人衰弱的听觉知觉障碍困扰着数百万人。这篇综述将考察中枢听觉系统在应对耳蜗性损伤时增益增强的证据。此外，它还将探讨这种增强的潜在细胞和分子机制，并讨论中枢增益增强对耳鸣和听觉过敏的贡献。目前的证据表明，具有不同时间和频谱分布的多种机制可能有助于中心增益增强。在中枢听觉系统的不同水平上解剖这些不同机制的作用，对于阐明中枢增益增强在耳鸣和听力亢进中的作用以及最重要的是开发治疗这些疾病的新方法是至关重要的。
Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural activity transmitted from the cochlea to the central auditory system. Despite a reduced cochlear output, neural activity from more central auditory structures is paradoxically enhanced at suprathreshold intensities. This compensatory increase in the central auditory activity in response to the loss of sensory input is referred to as central gain enhancement. Enhanced central gain is hypothesized to be a potential mechanism that gives rise to hyperacusis and tinnitus, two debilitating auditory perceptual disorders that afflict millions of individuals. This review will examine the evidence for gain enhancement in the central auditory system in response to cochlear damage. Further, it will address the potential cellular and molecular mechanisms underlying this enhancement and discuss the contribution of central gain enhancement to tinnitus and hyperacusis. Current evidence suggests that multiple mechanisms with distinct temporal and spectral profiles are likely to contribute to central gain enhancement. Dissecting the contributions of these different mechanisms at different levels of the central auditory system is essential for elucidating the role of central gain enhancement in tinnitus and hyperacusis and, most importantly, the development of novel treatments for these disorders.
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影响因子：
16.2
作者：
Atallah BV;Bruns W;Carandini M;Scanziani M
通讯作者：
Scanziani M
影响因子：
--
作者：
Carcea, Ioana;Froemke, Robert C.
通讯作者：
Froemke, Robert C.
影响因子：
1.7
作者：
Alkhatib, Ala;Biebel, Ulrich W.;Smolders, Jean W. T.
通讯作者：
Smolders, Jean W. T.
影响因子：
2.7
作者：
Andersson, G;Lindvall, N;Carlbring, P
通讯作者：
Carlbring, P
影响因子：
1.7
作者：
Bledsoe, SC;Nagase, S;Altschuler, RA
通讯作者：
Altschuler, RA