Longitudinal analysis of antigen specific response in individuals with Schistosoma mansoni infection in an endemic area of Minas Gerais, Brazil.
Longitudinal analysis of antigen specific response in individuals with Schistosoma mansoni infection in an endemic area of Minas Gerais, Brazil.
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DOI：
10.1093/trstmh/trt091
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发表时间：
2013-12
影响因子：
2.2
通讯作者：
Correa-Oliveira R
中科院分区：
文献类型：
--
作者：
Matoso LF;Oliveira-Prado R;Abreu MN;Fujiwara RT;Loverde PT;Kloos H;Gazzinelli A;Correa-Oliveira R
免疫流行病学研究表明，IgE和IgG4抗体与年龄以及对感染的抵抗力和易感性有关。可溶性虫卵抗原(SEA)的IgE和IgG4反应可用于感染和治疗后状态的血清学分析。本研究旨在评价曼氏血吸虫感染与抗SEA IgG4和IgE反应性的关系，并确定这些反应性是否可以作为感染的生物标志物。2001至2009年间，进行了一项纵向研究，收集了127人的寄生虫学和血液标本以及社会经济和水接触信息。所有曼氏葡萄球菌感染阳性的患者都得到了治疗。2001年血吸虫病患病率为59%，虫卵数几何均数为61.05,2009年分别降至26.8%和8.78。在所有时间点，感染者的IgG4抗SEA反应性均显著高于非感染者。受试者工作特征(ROC)区分析表明，抗SEA抗体IgG4可在各时间点预测曼氏血吸虫感染。IgG4抗SEA反应性可作为免疫监测流行区曼氏血吸虫感染情况的生物标志物。
Immunoepidemiologic studies have shown a relationship between IgE and IgG4 antibodies with age and with resistance and susceptibility to infection. It is believed that the IgE and IgG4 responses to soluble egg antigen (SEA) can be used for serological analysis of infection and post-treatment status. This study aimed to evaluate the association between Schistosoma mansoni infection and anti-SEA IgG4 and IgE reactivities, and determine whether these reactivities could be used as biomarkers of infection. Between 2001 and 2009, a longitudinal study was performed in which parasitologic and blood specimens and socioeconomic and water-contact information were collected from 127 individuals. All patients positive for S. mansoni infection were treated. Schistosomiasis prevalence and the geometric mean of the egg count in 2001 were 59% and 61.05, respectively, decreasing to 26.8% and 8.78 in 2009. IgG4 anti-SEA reactivity in infected individuals was significantly higher than that in uninfected individuals at all time points. Analysis of receiver-operating characteristic (ROC) area showed that the IgG4 anti-SEA antibodies were able to predict infection by S. mansoni at each time point. IgG4 anti-SEA reactivity can be used as a biomarker for immune monitoring of the presence of infection with S. mansoni in endemic areas.
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影响因子：
2.7
作者：
da Frota, Sabrina Menezes;Carneiro, Teiliane Rodrigues;Moraes Bezerra, Fernando Schemelzer
通讯作者：
Moraes Bezerra, Fernando Schemelzer
DOI：
10.1590/s0074-02762010000400037
发表时间：
2010-07-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Enk, Martin Johannes;Lima, Anna Carolina Lustosa;Schall, Virginia Torres
通讯作者：
Schall, Virginia Torres
影响因子：
3.3
作者：
Gazzinelli, A;Bethony, J;Kloos, H
通讯作者：
Kloos, H
影响因子：
6.4
作者：
Grogan, JL;Kremsner, PG;Yazdanbakhsh, M
通讯作者：
Yazdanbakhsh, M
DOI：
10.4269/ajtmh.2000.62.57
发表时间：
2000-01-01
影响因子：
3.3
作者：
Caldas, IR;Correa-Oliveira, R;Gazzinelli, G
通讯作者：
Gazzinelli, G