The observed association between maternal anxiety and adolescent asthma: children of twin design suggest familial effects.
The observed association between maternal anxiety and adolescent asthma: children of twin design suggest familial effects.
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DOI：
10.1371/journal.pone.0066040
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Almqvist C
中科院分区：
文献类型：
--
作者：
Havland I;Lundholm C;Lichtenstein P;Neiderhiser JM;Ganiban JM;Spotts EL;Walum H;Reiss D;Almqvist C
以往的研究表明，母亲的焦虑与青少年儿童的哮喘有关，但机制尚不清楚。调查母亲焦虑与母亲、自我和登记报告的青少年儿童哮喘之间的关系，以及在控制家族混杂因素（共同的环境和遗传因素）后，这种关系是否仍然存在。来自瑞典的双胞胎和后代研究，包括1691名母亲（1058对双胞胎）和他们的青少年孩子。采用逻辑回归分析了母亲自我报告的焦虑（贝克焦虑量表（BAI）和卡罗林斯卡人格量表（KSP）躯体或精神焦虑）与基于主观（母亲或儿童报告）或客观（基于登记的诊断和药物治疗）测量的哮喘之间的关联。双胞胎的孩子的设计被用来探索是否基因或环境有助于协会。母亲BAI焦虑（OR 2.02，CI 1.15-3.55）与母亲报告的青少年哮喘显著相关。母亲KSP躯体焦虑（OR 1.74，CI 1.04-2.91）和精神焦虑（OR 1.74，CI 1.05-2.86）与青春期儿童报告的呼吸困难显著相关。与此相反，母亲焦虑与哮喘诊断或药物治疗登记结果的风险增加无关。在调整协变量和双胞胎子女分析后，结果仍然存在，这表明这种关联是由于家族混杂。我们发现母亲的焦虑和子女的哮喘或呼吸困难，这可能是由于家庭的影响主观报告之间的一些关联。解释这种家族性混杂的一个可能的候选人是与焦虑和哮喘主观测量相关的遗传性人格特征。
Previous studies indicate that maternal anxiety is associated with asthma in the adolescent child, but mechanisms are unclear. To investigate the association between maternal anxiety and maternal, self- and register-based report of asthma in the adolescent child, and whether the association remains after control of familial confounding (shared environmental and genetic factors). From the Twin and Offspring Study of Sweden, 1691 mothers (1058 twins) and their adolescent child were included. The association between maternal self-reported anxiety (Beck Anxiety Inventory (BAI) and Karolinska Scales of Personality (KSP) somatic or psychic anxiety) and asthma based on subjective (maternal or child report) or objective (register-based diagnosis and medication) measures were analysed using logistic regression. The children-of-twins design was used to explore whether genes or environment contribute to the association. Maternal BAI anxiety (OR 2.02, CI 1.15–3.55) was significantly associated with adolescent asthma reported by the mother. Maternal KSP somatic anxiety (OR 1.74, CI 1.04–2.91) and psychic anxiety (OR 1.74, CI 1.05–2.86) was significantly associated with breathlessness reported by the adolescent child. In contrast, maternal anxiety was not associated with increased risk for the register-based outcomes of asthma diagnosis or medication. The results remained also after adjusting for covariates and the children-of-twins analyses which indicate that the association was due to familial confounding. We found some associations between maternal anxiety and subjectively reported offspring asthma or breathlessness which may be due to familial effects. A likely candidate for explaining this familial confounding is heritable personality traits associated with both anxiety and subjective measures of asthma.
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影响因子：
14.2
作者：
Cookson, Hannah;Granell, Raquel;Joinson, Carol;Ben-Shlomo, Yoav;Henderson, A. John
通讯作者：
Henderson, A. John
DOI：
10.1111/1469-7610.00196
发表时间：
2003-11-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
D'Onofrio, BM;Turkheimer, EN;Emery, RE
通讯作者：
Emery, RE
影响因子：
1.9
作者：
BUTZ, AM;ALEXANDER, C
通讯作者：
ALEXANDER, C
影响因子：
14.2
作者：
Calam, R;Gregg, L;Custovic, A
通讯作者：
Custovic, A
影响因子：
6.6
作者：
Enns, MW;Cox, BJ;Guertin, JE
通讯作者：
Guertin, JE