Cup to disc ratio by optical coherence tomography is abnormal in multiple sclerosis.
Cup to disc ratio by optical coherence tomography is abnormal in multiple sclerosis.
复制标题
DOI：
10.1016/j.jns.2010.12.011
复制
发表时间：
2011-03-15
影响因子：
4.4
通讯作者：
Calabresi, P. A.
中科院分区：
文献类型：
--
作者：
Syc, S. B.;Warner, C. V.;Saidha, S.;Farrell, S. K.;Conger, A.;Bisker, E. R.;Wilson, J.;Frohman, T. C.;Frohman, E. M.;Balcer, L. J.;Calabresi, P. A.
关键词：
使用谱域光学相干断层扫描（OCT）识别和表征多发性硬化症（MS）的杯盘比（CDR）和相关的视神经乳头异常。虽然CDR是由眼科医生在青光眼的评价中常规评估的，但CDR和相关的视神经乳头指标在MS中仍在很大程度上未被探索。Cirrus-HD（高密度）OCT用于评价105名MS患者和88名年龄匹配的健康个体的平均CDR、垂直CDR、视盘面积、视杯体积和神经视网膜边缘面积。在77例MS患者中评估了高对比度（100%）视力，2.5%低对比度字母视力和1.25%低对比度字母视力。双样本t检验用于分析健康对照组和MS患者之间OCT衍生的视神经乳头测量值。多变量回归（考虑年龄和性别）用于评估视神经乳头测量和视功能之间的关系。与健康对照组相比，MS患者的平均CDR（p=0.007）和垂直CDR（p=0.005）更大，而MS患者的神经视网膜边缘面积减少（p=0.001）。CDR随视网膜神经纤维层（RNFL）变薄而增加（r=-0.29，p=0.001）。垂直CDR较高的MS患者的2.5%低对比度（p=0.005）和1.25%低对比度字母视敏度（p=0.03）较低。CDR（由谱域OCT确定）在MS中异常，并与视觉功能相关。OCT衍生的CDR和相关的视神经乳头指标可能代表了一种客观的测量方法，通过该方法可以在治疗性MS试验中监测疾病进展和潜在的神经保护。
To identify and characterize cup to disc ratio (CDR) and related optic nerve head abnormalities in multiple sclerosis (MS) using spectral domain optical coherence tomography (OCT). While CDR is routinely assessed by ophthalmologists in the evaluation of glaucoma, CDR and related optic nerve head metrics remain largely unexplored in MS. Cirrus-HD (high density) OCT was used to evaluate average CDR, vertical CDR, optic disc area, optic cup volume and neuro-retinal rim area in 105 MS patients and 88 age-matched healthy individuals. High-contrast (100%) visual acuity, 2.5% low-contrast letter acuity and 1.25% low-contrast letter acuity were assessed in 77 MS patients. Two-sample t-tests were used in the analysis of OCT-derived optic nerve head measures between healthy controls and MS patients. Multivariate regression (accounting for age and gender) was used to assess relationships between optic nerve head measures and visual function. Average CDR (p=0.007) and vertical CDR (p=0.005) was greater in MS patients compared to healthy controls, while neuro-retinal rim area was decreased in MS patients (p=0.001). CDR increased with retinal nerve fiber layer (RNFL) thinning (r=−0.29, p=0.001). 2.5% low-contrast (p=0.005) and 1.25% low-contrast letter acuity (p=0.03) were lower in MS patients with higher vertical CDR. CDR (as determined by spectral domain OCT), is abnormal in MS and correlates with visual function. OCT derived CDR and related optic nerve head metrics may represent an objective measure by which to monitor disease progression, and potentially neuroprotection, in therapeutic MS trials.
登录
查看更多内容
影响因子：
13.7
作者：
Knight OJ;Chang RT;Feuer WJ;Budenz DL
通讯作者：
Budenz DL
影响因子：
4.4
作者：
Contreras, Ines;Rebolleda, Gema;Munoz-Negrete, Francisco J.
通讯作者：
Munoz-Negrete, Francisco J.
影响因子：
11.2
作者：
Trip, SA;Schlottmann, PG;Miller, DH
通讯作者：
Miller, DH
影响因子：
9.9
作者：
Pulicken, M.;Gordon-Lipkin, E.;Calabresi, P. A.
通讯作者：
Calabresi, P. A.
影响因子：
--
作者：
ARMALY, MF;SAYEGH, RE
通讯作者：
SAYEGH, RE