Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography.
Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography.
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DOI：
10.1016/j.ophtha.2008.12.032
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发表时间：
2009-07
期刊：
影响因子：
13.7
通讯作者：
Budenz DL
中科院分区：
文献类型：
--
作者：
Knight OJ;Chang RT;Feuer WJ;Budenz DL
确定正常受试者和青光眼患者中Stratus时域光学相干断层扫描（OCT）和Cirrus谱域OCT（Carl Zeiss Meditec，都柏林，CA）的视乳头周围视网膜神经纤维层（RNFL）厚度测量值之间的一致性。诊断试验或技术的评价。分析了130例正常人和青光眼患者的130只眼。根据视野标准将受试者分为正常（n=29）、疑似青光眼（n=12）、轻度青光眼（n=41）、中度青光眼（n=18）和重度青光眼（n=30）。在同一天，使用Stratus Fast RNFL和Cirrus 200 x 200视盘扫描测量每名受试者一只眼睛的乳头周围RNFL厚度，以确定一致性。两名操作员使用相同的仪器进行所有扫描。RNFL厚度测量的Student配对t检验、Pearson相关系数和Bland-Altman分析。青光眼组的平均年龄明显更大，分别为68.3±12.3岁和55.7±12.1岁。使用Stratus OCT的每个严重度组的平均RNFL厚度（平均值± SD，μm）分别为99.4 ± 13.2、94.5 ± 15.0、79.0 ± 14.5、62.7 ± 10.2和51.0 ± 8.9，分别对应于正常、可疑、轻度、中度和重度受试者。Cirrus OCT的相应测量值分别为92.0 ± 10.8、88.1 ± 13.5、73.3 ± 11.8、60.9 ± 8.3和55.3 ± 6.6。通过配对t检验，所有Stratus-Cirrus差异均具有统计学显著性（p < 0.001），中度组除外（p = 0.11）。对于平均RNFL，层云-卷云差与RNFL厚度之间也存在高度显著的线性关系（p < 0.001）。Bland-Altman图表明，在较薄的RNFL值，层云测量的系统差异小于卷云，但在较厚的RNFL测量较大。无法直接比较Stratus OCT和Cirrus OCT之间的RNFL厚度测量。临床医生应注意，Stratus的测量值通常高于Cirrus，除非RNFL非常薄，如严重青光眼。如果将Stratus仪器的测量结果与Cirrus仪器的测量结果进行比较，则必须考虑到这种差异。
To determine the agreement between peripapillary retinal nerve fiber layer (RNFL) thickness measurements from Stratus time domain optical coherence tomography (OCT) and Cirrus spectral domain OCT (Carl Zeiss Meditec, Dublin, CA) in normal subjects and glaucoma patients. Evaluation of diagnostic test or technology. One hundred thirty eyes from 130 normal subjects and glaucoma patients were analyzed. The subjects were divided into Normal (n=29), Glaucoma Suspect (n=12), Mild Glaucoma (n=41), Moderate Glaucoma (n=18), and Severe Glaucoma (n=30) by visual field criteria. Peripapillary RNFL thickness was measured with Stratus Fast RNFL and Cirrus 200 x 200 Optic Disc Scan on the same day in one eye of each subject to determine agreement. Two operators used the same instruments for all scans. Student paired t-testing, Pearson’s correlation coefficient, and Bland-Altman analysis of RNFL thickness measurements. The average age of the glaucoma group was significantly older at 68.3±12.3 years versus 55.7±12.1 years. The average RNFL thickness (mean ± SD, in μm) for each severity group with Stratus OCT was 99.4 ± 13.2, 94.5 ± 15.0, 79.0 ± 14.5, 62.7 ± 10.2, and 51.0 ± 8.9, corresponding to normal, suspects, mild, moderate, and severe subjects, respectively. For Cirrus OCT, the corresponding measurements were 92.0 ± 10.8, 88.1 ± 13.5, 73.3 ± 11.8, 60.9 ± 8.3, and 55.3 ± 6.6. All Stratus-Cirrus differences were statistically significant by paired t-testing (p < 0.001) except for the moderate group (p = 0.11). For average RNFL, there was a highly significant linear relationship between Stratus minus Cirrus difference and RNFL thickness as well (p < 0.001). Bland-Altman plots showed that the systematic difference of Stratus measurements are smaller than Cirrus at thinner RNFL values but larger at thicker RNFL measurements. RNFL thickness measurements between Stratus OCT and Cirrus OCT cannot be directly compared. Clinicians should be aware that measurements are generally higher with Stratus than Cirrus except when the RNFL is very thin as in severe glaucoma. This difference must be taken into account if comparing measurements made with a Stratus instrument to those of a Cirrus instrument.
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作者：
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KATZ, J;SOMMER, A;ANDERSON, DR
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影响因子：
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作者：
Budenz, Donald L.;Fredette, Marie-Josee;Anderson, Douglas R.
通讯作者：
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