A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes.
A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes.
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DOI：
10.1016/j.neuroimage.2008.12.033
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发表时间：
2009-04-15
期刊：
影响因子：
5.7
通讯作者：
McCarthy G
中科院分区：
文献类型：
--
作者：
Morey RA;Petty CM;Xu Y;Hayes JP;Wagner HR 2nd;Lewis DV;LaBar KS;Styner M;McCarthy G
高分辨率结构磁共振图像的大型数据库正在被整合，以定量研究大脑解剖结构、疾病进展、治疗方案以及基因对大脑结构的影响之间的关系。在如此大型的数据库中对大脑结构进行量化，神经解剖学专家使用手工描绘的方法实际上是无法完成的。相反，这项研究将依赖于能够可靠且准确地对数十个大脑区域进行分割和量化的自动化方法。目前，几乎没有可用于帮助临床研究小组选择此类工具的指导。因此，我们的目标是比较两种流行的全自动工具（FSL/FIRST和FreeSurfer）与专家手工描绘在海马体和杏仁核测量方面的性能。将每种自动化测量得出的体积与手工描绘进行比较，比较的指标包括体积重叠百分比、体积差异百分比、样本间相关性以及三维群体水平的形状分析。此外，针对一系列效应量计算了进行组间研究的样本量估计值。与手工描绘相比，FreeSurfer对海马体的测量在体积重叠方面更大，体积差异更小，相关性更高，并且其样本量估计值更接近手工描绘，而FIRST则不然。FreeSurfer对杏仁核的测量与手工描绘的相关性也比FIRST更高，但体积差异比FIRST更大。两种技术在体积重叠方面相当，样本量估计值也相似。与手工描绘相比，对海马体的三维形状分析表明，FreeSurfer比FIRST更准确，特别是在头部和尾部。然而，FIRST比FreeSurfer更准确地呈现杏仁核的形状，FreeSurfer会使杏仁核的前后表面膨胀。
Large databases of high-resolution structural MR images are being assembled to quantitatively examine the relationships between brain anatomy, disease progression, treatment regimens, and genetic influences upon brain structure. Quantifying brain structures in such large databases cannot be practically accomplished by expert neuroanatomists using hand-tracing. Rather, this research will depend upon automated methods that reliably and accurately segment and quantify dozens of brain regions. At present, there is little guidance available to help clinical research groups in choosing such tools. Thus, our goal was to compare the performance of two popular and fully automated tools, FSL/FIRST and FreeSurfer, to expert hand tracing in the measurement of the hippocampus and amygdala. Volumes derived from each automated measurement were compared to hand tracing for percent volume overlap, percent volume difference, across-sample correlation, and 3-D group-level shape analysis. In addition, sample size estimates for conducting between-group studies were computed for a range of effect sizes. Compared to hand tracing, hippocampal measurements with FreeSurfer exhibited greater volume overlap, smaller volume difference, and higher correlation than FIRST, and sample size estimates with FreeSurfer were closer to hand tracing. Amygdala measurement with FreeSurfer was also more highly correlated to hand tracing than FIRST, but exhibited a greater volume difference than FIRST. Both techniques had comparable volume overlap and similar sample size estimates. Compared to hand tracing, a 3-D shape analysis of the hippocampus showed FreeSurfer was more accurate than FIRST, particularly in the head and tail. However, FIRST more accurately represented the amygdala shape than FreeSurfer, which inflated its anterior and posterior surfaces.
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影响因子：
2.8
作者：
Tae, Woo Suk;Kim, Sam Soo;Kim, Keun Woo
通讯作者：
Kim, Keun Woo
影响因子：
2.2
作者：
McDonald, Carrie R.;Hagler, Donald J., Jr.;Halgren, Eric
通讯作者：
Halgren, Eric
影响因子：
4.5
作者：
Vita, A;De Peri, L;Dieci, A
通讯作者：
Dieci, A
影响因子：
--
作者：
Schiltz, Koja;Witzel, Joachim;Bogerts, Bernhard
通讯作者：
Bogerts, Bernhard
影响因子：
5
作者：
Provenzale, James M.;Barboriak, Daniel P.;Lewis, Darrell V.
通讯作者：
Lewis, Darrell V.