Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration.
Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration.
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DOI：
10.1146/annurev-neuro-100520-012117
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发表时间：
2021-07-08
影响因子：
13.9
通讯作者：
中科院分区：
文献类型：
--
作者：
我们的许多日常活动，如骑自行车上班或在嘈杂的咖啡馆里读书，以及高技能活动，如职业网球比赛或小提琴协奏曲，都依赖于大脑的能力，即根据我们行为的结果迅速对我们的行为进行即时调整。特别是，它们依赖于新皮层整合感觉器官提供的信息（自下而上的信息）与内部产生的信号（如期望或注意信号（自上而下的信息））的能力。这种整合发生在锥体细胞（pc）和它们的顶端长树突中，树突在第一层（L1）广泛地分支成树突簇。L1是新皮层的最外层，在皮层区域和物种中高度保守。重要的是，L1是自上而下信息的主要输入层，由一个丰富、密集的远程投射网络传递，向pc的丛状分支提供信号。在这里，我们讨论了我们对L1组成的理解的最新进展，并回顾了L1加工有助于诸如感觉知觉、跨模态整合、控制意识状态、注意力和学习等功能的证据。
Many of our daily activities, such as riding a bike to work or reading a book in a noisy cafe, and highly skilled activities, such as a professional playing a tennis match or a violin concerto, depend upon the ability of the brain to quickly make moment-to-moment adjustments to our behavior in response to the results of our actions. Particularly, they depend upon the ability of the neocortex to integrate the information provided by the sensory organs (bottom-up information) with internally generated signals such as expectations or attentional signals (top-down information). This integration occurs in pyramidal cells (PCs) and their long apical dendrite, which branches extensively into a dendritic tuft in layer 1 (L1). The outermost layer of the neocortex, L1 is highly conserved across cortical areas and species. Importantly, L1 is the predominant input layer for top-down information, relayed by a rich, dense mesh of long-range projections that provide signals to the tuft branches of the PCs. Here, we discuss recent progress in our understanding of the composition of L1 and review evidence that L1 processing contributes to functions such as sensory perception, cross-modal integration, controlling states of consciousness, attention, and learning.
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影响因子：
16.2
作者：
Bastos AM;Usrey WM;Adams RA;Mangun GR;Fries P;Friston KJ
通讯作者：
Friston KJ
影响因子：
3.5
作者：
Chen Z;Wimmer RD;Wilson MA;Halassa MM
通讯作者：
Halassa MM
影响因子：
2.5
作者：
BENEVENTO, LA;EBNER, FF
通讯作者：
EBNER, FF
内侧丘脑和腹内侧丘脑参与前额皮质中不同的 L1 回路。
影响因子：
16.2
作者：
Anastasiades PG;Collins DP;Carter AG
通讯作者：
Carter AG
影响因子：
7.7
作者：
Allaway KC;Muñoz W;Tremblay R;Sherer M;Herron J;Rudy B;Machold R;Fishell G
通讯作者：
Fishell G