The Female-Predominant Persistent Immune Dysregulation of the Post-COVID Syndrome.
The Female-Predominant Persistent Immune Dysregulation of the Post-COVID Syndrome.
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DOI：
10.1016/j.mayocp.2021.11.033
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发表时间：
2022-03
影响因子：
8.9
通讯作者：
Hurt RT
中科院分区：
文献类型：
--
作者：
Ganesh R;Grach SL;Ghosh AK;Bierle DM;Salonen BR;Collins NM;Joshi AY;Boeder ND Jr;Anstine CV;Mueller MR;Wight EC;Croghan IT;Badley AD;Carter RE;Hurt RT
描述梅奥诊所新冠肺炎术后护理诊所的首批108名患者的临床数据。在机构审查委员会批准后，我们审查了PCOCC在2021年1月19日至2021年4月29日期间看到的第一批108名患者的图表，并从电子病历中提取到标准化数据库中，以便于分析。通过专家评审将患者分成不同的表型。在我们诊所就诊的大多数患者是女性(75%；81/108)，发病时的中位年龄为46岁(四分位数范围为37至55岁)。所有患者均有SARS-CoV-2感染后的后遗症，表现为乏力(69例)、呼吸困难(23例)、肌肉酸痛(6例)、直立位(6例)、胸痛(3例)、头痛(1例)等6种临床表型。以疲劳为主的表型在女性中更常见，而以呼吸困难为主的表型在男性中更常见。61%的患者(女性为69%；P=0.0046)的IL-6水平高于C-反应蛋白和血沉的升高，分别为17%和20%。在我们的PCOCC中，我们观察到了几种不同的临床表型。疲劳是最常见的表现，并与IL-6水平升高和女性有关。呼吸困难在男性中更为常见，与IL-6水平升高无关。在SARS-CoV-2感染的急性后遗症患者中，IL-6水平比血沉和C反应蛋白更容易升高。
To describe the clinical data from the first 108 patients seen in the Mayo Clinic post–COVID-19 care clinic (PCOCC). After Institutional Review Board approval, we reviewed the charts of the first 108 patients seen between January 19, 2021, and April 29, 2021, in the PCOCC and abstracted from the electronic medical record into a standardized database to facilitate analysis. Patients were grouped into phenotypes by expert review. Most of the patients seen in our clinic were female (75%; 81/108), and the median age at presentation was 46 years (interquartile range, 37 to 55 years). All had post-acute sequelae of SARS-CoV-2 infection, with 6 clinical phenotypes being identified: fatigue predominant (n=69), dyspnea predominant (n=23), myalgia predominant (n=6), orthostasis predominant (n=6), chest pain predominant (n=3), and headache predominant (n=1). The fatigue-predominant phenotype was more common in women, and the dyspnea-predominant phenotype was more common in men. Interleukin 6 (IL-6) was elevated in 61% of patients (69% of women; P=.0046), which was more common than elevation in C-reactive protein and erythrocyte sedimentation rate, identified in 17% and 20% of cases, respectively. In our PCOCC, we observed several distinct clinical phenotypes. Fatigue predominance was the most common presentation and was associated with elevated IL-6 levels and female sex. Dyspnea predominance was more common in men and was not associated with elevated IL-6 levels. IL-6 levels were more likely than erythrocyte sedimentation rate and C-reactive protein to be elevated in patients with post-acute sequelae of SARS-CoV-2 infection.
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影响因子：
2.8
作者：
Islam, Mohammed F.;Cotler, Joseph;Jason, Leonard A.
通讯作者：
Jason, Leonard A.
影响因子：
11.8
作者：
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影响因子：
4.4
作者：
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通讯作者：
Whitelaw S
影响因子：
2.8
作者：
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通讯作者：
Greenhalgh T
影响因子：
--
作者：
Arnold, Lesley M.;Fan, Jinbo;Russell, I. Jon;Yunus, Muhammad B.;Khan, Muhammad Asim;Kushner, Irving;Olson, Jane M.;Iyengar, Sudha K.
通讯作者：
Iyengar, Sudha K.