Astaxanthin: sources, extraction, stability, biological activities and its commercial applications--a review.
Astaxanthin: sources, extraction, stability, biological activities and its commercial applications--a review.
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DOI：
10.3390/md12010128
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发表时间：
2014-01-07
期刊：
影响因子：
5.4
通讯作者：
Aswathanarayana RG
中科院分区：
文献类型：
--
作者：
Ambati RR;Phang SM;Ravi S;Aswathanarayana RG
目前，人们对来源于天然资源的生物活性化合物，特别是能够有效作用于涉及各种疾病的分子靶标的化合物非常感兴趣。虾青素（3，3 ′-dihydroxy-β，β′-carotene-4，4 ′-dione）是一种叶黄素类胡萝卜素，存在于雨生红球藻、小球藻、绿球藻和红酵母中。在H.雨生植物我们最近发表的数据，虾青素提取，分析，稳定性研究，其生物活性的结果添加到这篇综述文章。根据我们的研究结果和现有文献，虾青素在体外和体内模型中显示出潜在的生物活性。这些研究强调了虾青素的影响及其对动物和人类新陈代谢的有益作用。以红球藻生物质作为虾青素的来源，提高了动物对虾青素的生物利用度。作为营养补充剂、抗氧化剂和抗癌剂，虾青素可预防糖尿病、心血管疾病和神经退行性疾病，还可刺激免疫。虾青素产品以片剂、胶囊、糖浆、油、软凝胶、乳膏、生物质和颗粒状粉末的剂型用于商业应用。虾青素专利申请可用于食品，饲料和营养应用。本文综述了虾青素的来源、提取、分析、稳定性、生物学活性、健康益处及其商业应用。
There is currently much interest in biological active compounds derived from natural resources, especially compounds that can efficiently act on molecular targets, which are involved in various diseases. Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4′-dione) is a xanthophyll carotenoid, contained in Haematococcus pluvialis, Chlorella zofingiensis, Chlorococcum, and Phaffia rhodozyma. It accumulates up to 3.8% on the dry weight basis in H. pluvialis. Our recent published data on astaxanthin extraction, analysis, stability studies, and its biological activities results were added to this review paper. Based on our results and current literature, astaxanthin showed potential biological activity in in vitro and in vivo models. These studies emphasize the influence of astaxanthin and its beneficial effects on the metabolism in animals and humans. Bioavailability of astaxanthin in animals was enhanced after feeding Haematococcus biomass as a source of astaxanthin. Astaxanthin, used as a nutritional supplement, antioxidant and anticancer agent, prevents diabetes, cardiovascular diseases, and neurodegenerative disorders, and also stimulates immunization. Astaxanthin products are used for commercial applications in the dosage forms as tablets, capsules, syrups, oils, soft gels, creams, biomass and granulated powders. Astaxanthin patent applications are available in food, feed and nutraceutical applications. The current review provides up-to-date information on astaxanthin sources, extraction, analysis, stability, biological activities, health benefits and special attention paid to its commercial applications.
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影响因子：
2.4
作者：
Chang, Chi-Huang;Chen, Chung-Yin;Peng, Chiung-Huei
通讯作者：
Peng, Chiung-Huei
影响因子：
2.4
作者：
Augusti PR;Quatrin A;Somacal S;Conterato GM;Sobieski R;Ruviaro AR;Maurer LH;Duarte MM;Roehrs M;Emanuelli T
通讯作者：
Emanuelli T
astaxanthin：心血管疾病中潜在的治疗剂。
影响因子：
5.4
作者：
Fassett RG;Coombes JS
通讯作者：
Coombes JS
影响因子：
8.8
作者：
Anarjan, Navideh;Tan, Chin Ping
通讯作者：
Tan, Chin Ping
影响因子：
4.3
作者：
Gross, GJ;Hazen, SL;Lockwood, SF
通讯作者：
Lockwood, SF