Astaxanthin prevents changes in the activities of thioredoxin reductase and paraoxonase in hypercholesterolemic rabbits.
Astaxanthin prevents changes in the activities of thioredoxin reductase and paraoxonase in hypercholesterolemic rabbits.
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DOI：
10.3164/jcbn.11-74
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发表时间：
2012-07
影响因子：
2.4
通讯作者：
Emanuelli T
中科院分区：
文献类型：
--
作者：
Augusti PR;Quatrin A;Somacal S;Conterato GM;Sobieski R;Ruviaro AR;Maurer LH;Duarte MM;Roehrs M;Emanuelli T
本研究探讨了抗氧化剂虾青素对对氧磷酶和硫氧还蛋白还原酶活性以及对其他氧化应激参数和高胆固醇血症兔的血脂谱的影响。兔子被喂食标准或高胆固醇血症饮食单独或补充50，100和500毫克/100克的虾青素60天。血清中的抗氧化酶活性，脂质谱和氧化应激标志物进行了评价。高胆固醇饮食增加脂质，包括不饱和脂肪酸水平，而它降低饱和脂肪酸水平。这些变化伴随着氧化低密度脂蛋白和氧化低密度脂蛋白抗体水平的增加，以及脂质和蛋白质氧化。虾青素（100和500毫克/100克）防止高胆固醇血症诱导的蛋白质氧化，而500毫克/100克的虾青素本身降低蛋白质氧化。超氧化物歧化酶和硫氧还蛋白还原酶的活性增强，而对氧磷酶的活性抑制高胆固醇血症兔。所有剂量的虾青素防止硫氧还蛋白还原酶和对氧磷酶活性的变化。这种效果是不相关的直接影响，虾青素对这些酶，因为在体外虾青素增强硫氧还蛋白还原酶，对氧磷酶活性没有影响。虾青素可以通过恢复硫氧还蛋白还原酶和对氧磷酶的活性来帮助心血管疾病。
This study explored the effects of the antioxidant astaxanthin on paraoxonase and thioredoxin reductase activities as well as on other oxidative stress parameters and on the lipid profile in hypercholesterolemic rabbits. Rabbits were fed a standard or a hypercholesterolemic diet alone or supplemented with 50, 100 and 500 mg/100 g of astaxanthin for 60 days. Antioxidant enzymes activities, lipid profile and oxidative stress markers were evaluated in the serum. The hypercholesterolemic diet increased lipids, including unsaturated fatty acids level, whereas it decreased saturated fatty acids level. These changes were accompanied by increased levels of oxidized low-density lipoprotein and oxidized low-density lipoprotein antibodies, as well as lipid and protein oxidation. Astaxanthin (100 and 500 mg/100 g) prevented hypercholesterolemia-induced protein oxidation, whereas 500 mg/100 g of astaxanthin decreased protein oxidation per se. The activities of superoxide dismutase and thioredoxin reductase were enhanced, whereas paraoxonase activity was inhibited in hypercholesterolemic rabbits. All astaxanthin doses prevented changes in thioredoxin reductase and paraoxonase activities. This effect was not related to a direct effect of astaxanthin on these enzymes, because in vitro astaxanthin enhanced thioredoxin reductase and had no effect on paraoxonase activity. Astaxanthin could be helpful in cardiovascular diseases by restoring thioredoxin reductase and paraoxonase activities.
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影响因子：
6.1
作者：
Bolayirli, Ibrahim Murat;Aslan, Mahmure;Seven, Arzu
通讯作者：
Seven, Arzu
影响因子：
4.3
作者：
Kwon, E. Y.;Do, G. M.;Choi, M. S.
通讯作者：
Choi, M. S.
影响因子：
2.8
作者：
Duarte, Marta M. M. F.;Rocha, Joao B. T.;Schetinger, Maria R. C.
通讯作者：
Schetinger, Maria R. C.
影响因子：
8.7
作者：
Holvoet, P;Stassen, JM;Vanhaecke, J
通讯作者：
Vanhaecke, J
影响因子：
4.2
作者：
Bell, JG;McEvoy, J;Sargent, JR
通讯作者：
Sargent, JR