Mutational Landscape and Environmental Effects in Bladder Cancer.
Mutational Landscape and Environmental Effects in Bladder Cancer.
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DOI：
10.3390/ijms21176072
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发表时间：
2020-08-23
影响因子：
5.6
通讯作者：
Nonomura N
中科院分区：
文献类型：
--
作者：
Hayashi T;Fujita K;Hayashi Y;Hatano K;Kawashima A;McConkey DJ;Nonomura N
膀胱癌是泌尿系统最常见的癌症。虽然非肌层浸润性膀胱癌预后良好，但肌层浸润性膀胱癌促进转移，预后不良。已经报道了使用膀胱癌临床肿瘤样品的RNA序列的综合分析。这些报道暗示了在膀胱癌的发生和/或进展中起重要作用的候选基因和通路。每个突变的功能的进一步调查是必要的。有提示性证据表明，几种环境因素是膀胱癌的危险因素。吸烟、接触化学物质和气体、微生物和寄生虫感染引起的膀胱炎症、饮食和营养等环境因素可能会诱导多种基因突变并改变肿瘤微环境，例如免疫细胞和成纤维细胞。这些环境因素如何诱导膀胱癌发生和/或进展的详细机制仍不清楚。明确这些突变与生活方式的关系，有助于膀胱癌的预防和治疗。
Bladder cancer is the most common cancer of the urinary tract. Although nonmuscle-invasive bladder cancers have a good prognosis, muscle-invasive bladder cancers promote metastases and have a poor prognosis. Comprehensive analyses using RNA sequence of clinical tumor samples in bladder cancer have been reported. These reports implicated the candidate genes and pathways that play important roles in carcinogenesis and/or progression of bladder cancer. Further investigations for the function of each mutation are warranted. There is suggestive evidence for several environmental factors as risk factors of bladder cancer. Environmental factors such as cigarette smoking, exposure to chemicals and gases, bladder inflammation due to microbial and parasitic infections, diet, and nutrition could induce several genetic mutations and alter the tumor microenvironment, such as immune cells and fibroblasts. The detailed mechanism of how these environmental factors induce carcinogenesis and/or progression of bladder cancer remains unclear. To identify the relationship between the mutations and the lifestyle could be useful for prevention and treatment of bladder cancer.
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DOI：
10.1017/s0007114511001346
发表时间：
2011-10
期刊：
The British journal of nutrition
影响因子：
--
作者：
Brinkman MT;Karagas MR;Zens MS;Schned AR;Reulen RC;Zeegers MP
通讯作者：
Zeegers MP
影响因子：
6.6
作者：
Abufaraj, Mohammad;Tabung, Fred K.;Schernhammer, Eva
通讯作者：
Schernhammer, Eva
DOI：
10.1016/j.urolonc.2020.04.010
发表时间：
2020-09-01
影响因子：
2.7
作者：
Garg, Tullika;Young, Amanda J.;Kirchner, H. Lester
通讯作者：
Kirchner, H. Lester
影响因子：
6.4
作者：
Dugué PA;Hodge AM;Brinkman MT;Bassett JK;Shivappa N;Hebert JR;Hopper JL;English DR;Milne RL;Giles GG
通讯作者：
Giles GG
影响因子：
3.3
作者：
Cowan ML;Springer S;Nguyen D;Taheri D;Guner G;Mendoza Rodriguez MA;Wang Y;Kinde I;Del Carmen Rodriguez Pena M;VandenBussche CJ;Olson MT;Cunha I;Fujita K;Ertoy D;Kinzler K;Bivalacqua T;Papadopoulos N;Vogelstein B;Netto GJ
通讯作者：
Netto GJ