Transplantation of adipose tissue and stem cells: role in metabolism and disease.
Transplantation of adipose tissue and stem cells: role in metabolism and disease.
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DOI：
10.1038/nrendo.2010.20
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发表时间：
2010-04
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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人类和其他哺乳动物具有三种主要的脂肪库：内脏白色脂肪、皮下白色脂肪和棕色脂肪，每种脂肪库都具有独特的细胞自主特性。与可引起有害代谢影响的内脏脂肪相比，皮下白色脂肪和棕色脂肪具有潜在的有益代谢影响，包括改善葡萄糖稳态和增加能量消耗，这可能通过移植这些脂肪组织来转移。此外，脂肪含有脂肪来源的干细胞，这些干细胞已被证明具有多谱系特性，这可能对修复或替换各种细胞谱系具有价值。因此，现在正在探索脂肪移植作为一种可能的工具，以捕获皮下白色脂肪、棕色脂肪和脂肪干细胞的有益代谢作用。目前，脂肪移植主要作为研究生理学的工具进行探索，唯一应用于人类的是重建手术。最终，与其他治疗方法相比，应用脂肪移植治疗肥胖和代谢紊乱将取决于安全性、可靠性和有效性。
Humans and other mammals have three main fat depots - visceral white fat, subcutaneous white fat, and brown fat - each possessing unique cell-autonomous properties. In contrast to visceral fat which can induce detrimental metabolic effects, subcutaneous white fat and brown fat have potential beneficial metabolic effects, including improved glucose homeostasis and increased energy consumption, which might be transferred by transplantation of these fat tissues. In addition, fat contains adipose-derived stem cells that have been shown to have multilineage properties which may be of value in repair or replacement of various cell lineages. Thus, transplantation of fat is now being explored as a possible tool to capture the beneficial metabolic effects of subcutaneous white fat, brown fat, and adipose-derived stem cells. Currently, fat transplantation has been explored primarily as a tool to study physiology, with the only application to humans being reconstructive surgery. Ultimately, the application of fat transplantation for treatment of obesity and metabolic disorders will reside in the level of safety, reliability, and efficacy when compared to other treatments.
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DOI：
10.1242/dev.002642
发表时间：
2007-06
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
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通讯作者：
Dupin E
影响因子：
7.7
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通讯作者：
Reitman, ML
影响因子：
7.7
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通讯作者：
Juhan-Vague, I
影响因子：
5
作者：
Baik, I;Ascherio, A;Willett, WC
通讯作者：
Willett, WC
DOI：
10.1152/ajpendo.00187.2006
发表时间：
2006-11-01
影响因子：
5.1
作者：
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通讯作者：
Owens, Randall J.