Structures and Anti-Allergic Activities of Natural Products from Marine Organisms.
Structures and Anti-Allergic Activities of Natural Products from Marine Organisms.
复制标题
海洋生物天然产物的结构和抗过敏活性。
DOI：
10.3390/md21030152
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发表时间：
2023-02-25
期刊：
影响因子：
5.4
通讯作者：
Han B
中科院分区：
文献类型：
--
作者：
Chen N;Zhang S;Javeed A;Jian C;Liu Y;Sun J;Wu S;Fu P;Han B
近年来，过敏性疾病频繁发生，影响全球20%以上的人口。目前抗过敏药物的一线治疗主要包括外用皮质类固醇，以及抗组胺药物的辅助治疗，长期使用后存在不良副作用和耐药性。因此，从天然产物中寻找替代的抗过敏药物是至关重要的。高压、低温和低/缺乏光照导致海洋环境中高度功能化和多种功能的天然产物。本文综述了主要从真菌、细菌、大型藻类、海绵、软体动物和鱼类中获得的具有多种化学结构的抗过敏次级代谢产物，如多酚类、生物碱类、萜类、甾体类和肽类。利用莫伊进行分子对接模拟，进一步揭示了一些具有代表性的海洋抗过敏天然产物作用于H1受体的潜在机制。本综述不仅为了解海洋生物天然产物的结构和抗过敏活性提供了新的信息，也为海洋天然产物的免疫调节活性研究提供了有价值的参考。
In recent years, allergic diseases have occurred frequently, affecting more than 20% of the global population. The current first-line treatment of anti-allergic drugs mainly includes topical corticosteroids, as well as adjuvant treatment of antihistamine drugs, which have adverse side effects and drug resistance after long-term use. Therefore, it is essential to find alternative anti-allergic agents from natural products. High pressure, low temperature, and low/lack of light lead to highly functionalized and diverse functional natural products in the marine environment. This review summarizes the information on anti-allergic secondary metabolites with a variety of chemical structures such as polyphenols, alkaloids, terpenoids, steroids, and peptides, obtained mainly from fungi, bacteria, macroalgae, sponges, mollusks, and fish. Molecular docking simulation is applied by MOE to further reveal the potential mechanism for some representative marine anti-allergic natural products to target the H1 receptor. This review may not only provide insight into information about the structures and anti-allergic activities of natural products from marine organisms but also provides a valuable reference for marine natural products with immunomodulatory activities.
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影响因子：
4
作者：
Cai, Liang;Makhov, Alexander M.;Bear, James E.
通讯作者：
Bear, James E.
DOI：
10.4049/jimmunol.0801375
发表时间：
2009-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kato A;Chustz RT;Ogasawara T;Kulka M;Saito H;Schleimer RP;Matsumoto K
通讯作者：
Matsumoto K
影响因子：
64.8
作者：
Galli, Stephen J.;Tsai, Mindy;Piliponsky, Adrian M.
通讯作者：
Piliponsky, Adrian M.
影响因子：
7.1
作者：
Arts, ICW;Hollman, PCH
通讯作者：
Hollman, PCH
影响因子：
10.1
作者：
Carte, BK
通讯作者：
Carte, BK