Evaluation of the thyroid characteristics of patients with growth hormone-secreting adenomas
Evaluation of the thyroid characteristics of patients with growth hormone-secreting adenomas
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生长激素分泌腺瘤患者甲状腺特征的评估
DOI：
10.1186/s12902-019-0424-x
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发表时间：
2019-09
影响因子：
2.7
通讯作者：
Wang Xiaodong
中科院分区：
文献类型：
--
作者：
Xu Dianshuang;Wu Bolin;Li Xiaoju;Cheng Yunjiu;Chen Dubo;Fang Yuefeng;Du Qiu;Chen Zhiyong;Wang Xiaodong
研究背景肢端肥大症与甲状腺疾病密切相关。然而，甲状腺结节的临床特点，在个人与肢端肥大症谁目前与甲状腺diseases.MethodsOverall，134个连续参与者与生长激素（GH）分泌腺瘤（n= 67）和无功能（NF）垂体腺瘤（n = 67）被招募从门诊和住院病人部的第一附属医院，2015年8月至2017年8月，暨南大学。使用超声系统进行甲状腺超声检查。细针穿刺活检的细胞病理学结果由病理学家根据Bethesda系统进行分析。21例生长激素分泌腺瘤和甲状腺疾病进行了经蝶垂体腺瘤切除术，并随访了1 year.ResultsThe甲状腺疾病的患病率增加的生长激素分泌腺瘤组相比，在NF垂体腺瘤组。与NF型垂体腺瘤合并甲状腺疾病患者相比，GH分泌腺瘤合并甲状腺疾病患者的低回声、等回声、异质性和血管性甲状腺结节数量增加。最后，我们发现治愈组的实性结节的形态在手术后与手术前相比显著减少，而囊性结节的形态在手术后与手术前相比显著增加。治愈组术后甲状腺结节数量较术前明显减少，且异质性结节和血管性结节数量明显减少。然而，手术后的甲状腺结节的特点并没有改变与手术前相比，在noncured group.ConclusionsThe低回声，等回声，异质性，和血管甲状腺结节的数量增加GH分泌腺瘤的患者。在这些患者中，手术导致了从实性结节到囊性结节的显著变化，也减少了异质性和血管性甲状腺结节的数量。
BackgroundAcromegaly is highly associated with thyroid disorders. However, the clinical characteristics of thyroid nodules in individuals with acromegaly who present with thyroid diseases have not been completely elucidated.MethodsOverall, 134 consecutive participants with growth hormone (GH)-secreting adenoma (n= 67) and non-functioning (NF) pituitary adenoma (n = 67) were recruited from the outpatient and inpatient patient department of The First Affiliated Hospital, Jinan University from August 2015 to August 2017. Thyroid ultrasonography was performed using an ultrasound system. The cytopathological results of fine-needle aspiration biopsy were analyzed by a pathologist according to the Bethesda system. Twenty-one patients with GH-secreting adenoma and thyroid disease underwent transsphenoidal pituitary adenoma resection and were followed up for 1 year.ResultsThe prevalence of thyroid disease increased in the GH-secreting adenoma group compared with that in the NF pituitary adenoma group. The number of hypoechoic, isoechogenic, heterogeneous, and vascular thyroid nodules increased in patients with GH-secreting adenoma plus thyroid disease compared with that in patients with NF pituitary adenoma plus thyroid disease. Finally, we found significant decreases in the morphology of solid nodules and significant increases in the morphology of cystic nodules after surgery compared with those before surgery in the cured group. Moreover, the numbers of heterogeneous and vascular thyroid nodules decreased significantly after surgery compared with those before surgery in the cured group. However, the characteristics of the thyroid nodules did not change after surgery compared with those before surgery in the non-cured group.ConclusionsThe numbers of hypoechoic, isoechoic, heterogeneous, and vascular thyroid nodules increased in patients with GH-secreting adenomas. In these patients, surgery resulted in significant changes from solid to cystic nodules and also reduced the numbers of heterogeneous and vascular thyroid nodules.
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影响因子：
5.3
作者：
通讯作者：
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影响因子：
8.4
作者：
N. Onoda;E. Ohmura;T. Tsushima;Y. Ohba;N. Emoto;O. Isozaki;Ya. Sato;K. Shizume;H. Demura
通讯作者：
N. Onoda;E. Ohmura;T. Tsushima;Y. Ohba;N. Emoto;O. Isozaki;Ya. Sato;K. Shizume;H. Demura
影响因子：
3.5
作者：
Cibas, Edmund S.;Ali, Syed Z.
通讯作者：
Ali, Syed Z.
影响因子：
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作者：
Gasperi, M;Martino, E;Liuzzi, A
通讯作者：
Liuzzi, A
影响因子：
5.8
作者：
Curto, Lorenzo;Giovinazzo, Salvatore;Ruggeri, Rosaria Maddalena
通讯作者：
Ruggeri, Rosaria Maddalena