Telomere length and verbal learning in bipolar disorders.
Telomere length and verbal learning in bipolar disorders.
复制标题
双相情感障碍的端粒长度和语言学习。
DOI：
10.1016/j.jad.2023.07.087
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发表时间：
2023
影响因子：
6.6
通讯作者：
Mlakar V
中科院分区：
文献类型：
--
作者：
Mlakar V
最近的研究表明，双相情感障碍患者的衰老过程加快，端粒长度缩短，认知功能较差。双相情感障碍认知功能的神经生物学基础尚未建立。我们预计，加速老化缩短端粒长度所示，将与认知性能降低双相情感障碍，特别是对老化敏感的功能，如记忆和learning.MethodsThe研究包括647名参与者（双相情感障碍[n = 246]和健康对照[n = 401]）。所有参与者都接受了标准化的神经心理学测试，包括工作记忆，执行功能，处理速度，言语学习和言语记忆。通过血液测量白细胞端粒长度，并通过定量实时聚合酶链反应（qPCR）测定，提供端粒与单拷贝比（T/S比）。T/S比值被用来估计每个参与者的平均端粒长度。所有的分析都调整了药物，每日限定剂量（DDD），实足年龄，性别和ethnicity.ResultsPatients有较短的端粒长度比健康对照组（科恩的sd = 0.11，p = 0.01）。在患者中，观察到语言学习和端粒长度呈正相关（β = 0.14，p = 0.025），沿着语言记忆和端粒长度的趋势（β = 0.11，p = 0.07）。在患者或对照组中没有观察到端粒长度和认知功能的其他相关性（p> 0.1）。然而，端粒长度对双相情感障碍认知功能的作用似乎有限。
IntroductionRecent studies indicate accelerated ageing processes, shorter telomere length and poorer cognitive functioning in patients with bipolar disorder. The neurobiology underlying cognitive function in bipolar disorder is yet to be established. We anticipated that accelerated ageing as indicated by shortened telomere length, would be associated with reduced cognitive performance in bipolar disorder, particularly for ageing sensitive functions such as memory and learning.MethodsThe study consisted of 647 participants (bipolar disorder [n= 246] and healthy controls [n= 401]). All participants underwent a standardized neuropsychological test battery, including working memory, executive functioning, processing speed, verbal learning, and verbal memory. Leucocyte telomere length was measured via blood and determined by quantitative real-time Polymerase Chain Reaction (qPCR) providing a telomere to single copy ratio (T/S ratio). The T/S ratio was used as an estimate of the mean telomere length of each participant. All analyses were adjusted for medication, Daily Defined Dose (DDD), chronological age, sex, and ethnicity.ResultsPatients had shorter telomere lengths than healthy controls (Cohen'sd= 0.11,p= 0.01). Within patients', a positive association was observed for verbal learning and telomere length (β = 0.14,p= 0.025), along with a trend for verbal memory and telomere length (β = 0.11,p= 0.07). No other associations were observed for telomere length and cognitive functioning in the patient or the control group (p>0.1).ConclusionOur study may suggest poorer brain health in bipolar disorder as indexed by shorter telomere length and reduced learning correlates. However, the role of telomere length on cognitive functioning in bipolar disorder seems limited.
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