Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the National Comorbidity Survey.
Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the National Comorbidity Survey.
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DOI：
10.1111/j.1360-0443.2010.02902.x
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Kessler RC
中科院分区：
文献类型：
--
作者：
Swendsen J;Conway KP;Degenhardt L;Glantz M;Jin R;Merikangas KR;Sampson N;Kessler RC
精神障碍和物质依赖的共病是有据可查的，但在社区样本的前瞻性调查是罕见的。本研究探讨了原发性精神障碍作为尼古丁、酒精和非法药物使用、滥用和滥用依赖的风险因素的作用。NCS是一项具有全国代表性的精神和物质障碍调查，在美国进行于1990年至1992年。在2001-2003年，即基线调查十年后，第二次全国统计调查重新访问了非华语受访者的概率子样本。在NCS-2中，共有5，001名非华语受访者接受了重新访问（占基线样本的87.6%）。综合分析表明，基线精神障碍对随访期间尼古丁、酒精和非法药物依赖伴滥用的发作构成了显著的前瞻性风险。观察到行为障碍和先前的物质使用状况以及某些情绪和焦虑障碍之间存在特别强烈和一致的关联。条件分析表明，许多观察到的关联仅限于特定类别的使用，滥用或依赖，包括几种精神障碍，在综合分析中是非显着的预测因素。结果表明，继发性物质使用障碍可能会大大减少通过预防原发性精神障碍。许多精神障碍与后来物质使用状况的风险增加有关，但在使用、滥用和依赖滥用的类别中观察到这些关联的重要差异。这些前瞻性研究结果对针对物质使用障碍的预防和治疗策略的精确性具有影响。
The comorbidity of mental disorders and substance dependence is well-documented, but prospective investigations in community samples are rare. This investigation examines the role of primary mental disorders as risk factors for the later onset of nicotine, alcohol and illicit drug use, abuse, and dependence with abuse. The NCS was a nationally representative survey of mental and substance disorders in the US carried out in 1990 1992. The NCS-2 re-interviewed a probability sub-sample of NCS respondents in 2001-2003, a decade after the baseline survey. A total of 5,001 NCS respondents were re-interviewed in the NCS-2 (87.6% of baseline sample). Aggregate analyses demonstrated significant prospective risks posed by baseline mental disorders for the onset of nicotine, alcohol and illicit drug dependence with abuse over the follow-up period. Particularly strong and consistent associations were observed for behavioral disorders and previous substance use conditions, as well as for certain mood and anxiety disorders. Conditional analyses demonstrated that many observed associations were limited to specific categories of use, abuse or dependence, including several mental disorders that were nonsignificant predictors in the aggregate analyses. Results suggest that secondary substance use disorders might be reduced substantially through the prevention of primary mental disorders. Many mental disorders are associated with an increased risk of later substance use conditions but important differences in these associations are observed across the categories of use, abuse and dependence with abuse. These prospective findings have implications for the precision of prevention and treatment strategies targeting substance use disorders.
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影响因子：
120.7
作者：
GLASSMAN, AH;HELZER, JE;JOHNSON, J
通讯作者：
JOHNSON, J
影响因子：
4.2
作者：
Behrendt, S.;Wittchen, H. -U.;Beesdo, K.
通讯作者：
Beesdo, K.
影响因子：
6.3
作者：
Frisher, M;Crome, I;Croft, P
通讯作者：
Croft, P
影响因子：
3.8
作者：
Dierker, Lisa;He, Jianping;Kalaydjian, Amanda;Swendsen, Joel;Degenhardt, Louisa;Glantz, Meyer;Conway, Kevin;Anthony, James;Chiu, Wai Tat;Sampson, Nancy A.;Kessler, Ronald;Merikangas, Kathleen
通讯作者：
Merikangas, Kathleen
影响因子：
5.3
作者：
Compton, WM;Conway, KP;Grant, BF
通讯作者：
Grant, BF