Novel vaccine development strategies for inducing mucosal immunity.
Novel vaccine development strategies for inducing mucosal immunity.
复制标题
新型疫苗开发策略可诱导粘膜免疫。
DOI：
10.1586/erv.11.196
复制
发表时间：
2012-03
影响因子：
6.2
通讯作者：
Fujihashi K
中科院分区：
文献类型：
--
作者：
Fujkuyama Y;Tokuhara D;Kataoka K;Gilbert RS;McGhee JR;Yuki Y;Kiyono H;Fujihashi K
为了产生针对粘膜病原体的保护性免疫反应，疫苗接种的递送途径和佐剂是重要的。然而，宿主通过对粘膜抗原的耐受性反应而不是免疫激活来努力维持粘膜稳态。因此，通过疫苗接种诱导粘膜免疫是一项相当困难的任务，经常使用强效的粘膜佐剂、载体或其他特殊的递送系统，特别是在老年人中。利用共同的粘膜免疫系统，以粘膜树突状细胞和微褶上皮细胞为靶点，可促进诱导有效的粘膜免疫。因此，新的免疫途径和抗原递送系统也显示出开发针对各种病原体的有效和安全的粘膜疫苗的巨大潜力。本综述的目的是介绍几种最近的方法来诱导粘膜免疫疫苗，重点是粘膜组织靶向，新的免疫途径和递送系统。定义粘膜疫苗的机制与它们的有效性和安全性一样重要，在本文中，讨论了最近可能加速粘膜疫苗开发进展的方法的例子。
To develop protective immune responses against mucosal pathogens, the delivery route and adjuvants for vaccination are important. The host, however, strives to maintain mucosal homeostasis by responding to mucosal antigens with tolerance, instead of immune activation. Thus, induction of mucosal immunity through vaccination is a rather difficult task, and potent mucosal adjuvants, vectors or other special delivery systems are often used, especially in the elderly. By taking advantage of the common mucosal immune system, the targeting of mucosal dendritic cells and microfold epithelial cells may facilitate the induction of effective mucosal immunity. Thus, novel routes of immunization and antigen delivery systems also show great potential for the development of effective and safe mucosal vaccines against various pathogens. The purpose of this review is to introduce several recent approaches to induce mucosal immunity to vaccines, with an emphasis on mucosal tissue targeting, new immunization routes and delivery systems. Defining the mechanisms of mucosal vaccines is as important as their efficacy and safety, and in this article, examples of recent approaches, which will likely accelerate progress in mucosal vaccine development, are discussed.
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DOI：
10.1084/jem.20011502
发表时间：
2002-01-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campbell DJ;Butcher EC
通讯作者：
Butcher EC
影响因子：
5.5
作者：
Amidi, Maryam;Romeijn, Stefan G.;Jiskoot, Wim
通讯作者：
Jiskoot, Wim
影响因子：
4.4
作者：
Campbell, JJ;Brightling, CE;Wardlaw, AJ
通讯作者：
Wardlaw, AJ
影响因子：
2.9
作者：
Chodosh, J;Nordquist, RE;Kennedy, RC
通讯作者：
Kennedy, RC
影响因子：
5.5
作者：
Ernst, William A.;Kim, Hyung J.;Fujii, Gary
通讯作者：
Fujii, Gary