Risks and benefits of menopausal hormone therapy in postmenopausal Chinese women.
Risks and benefits of menopausal hormone therapy in postmenopausal Chinese women.
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DOI：
10.1097/gme.0b013e31824362ff
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Yang YX
中科院分区：
文献类型：
--
作者：
Su IH;Chen YC;Hwang WT;Liu Z;Su TP;Chen TJ;Barnhart KT;Yang YX
Assess risks and benefits of conjugated equine estrogen (CEE) and medroxyprogesterone (MPA) in postmenopausal Chinese women. A retrospective cohort study was undertaken using the Taiwan National Health Insurance Research Database, a population-based healthcare claims dataset. Eligible women aged 50–79 were classified as exposed to CEE 0.625mg/day, MPA 5.0mg/day (E+P, n=4712) or CEE 0.625mg/day alone (E-only, n=1208) and age-matched to unexposed women (n=10,125). Follow up was complete on 96% of participants. The primary outcomes were coronary heart disease (CHD) and invasive breast cancer. The global index summarized risks of primary outcomes, stroke, pulmonary embolism, colon and endometrial cancers, hip fractures and death. Time-to-event analyses were performed. Median durations of exposure in the E+P and E-only groups were 6.9 months and 9 months, respectively. Median follow-up was 110 months. Hazard ratios (95%CI) for E+P exposure were: myocardial infarction (MI), 0.78 (0.51–1.19); CHD death, 1.21 (0.53–2.70); breast cancer, 1.48 (1.20–1.83); global index, 0.79 (0.72–0.87). Hazard ratios for E-only exposure were: MI, 0.76 (0.35–1.68); CHD death, 0.57 (0.11–2.80); breast cancer 1.44 (0.99–2.10); global index, 1.09 (0.92–1.28). Per 10,000 person-years, there were 12 excess breast cancer cases with E+P exposure; there were 39 fewer global index events with E+P exposure. Adjusting for age, statin and aspirin use, hypercholesterolemia, diabetes and hypertension did not significantly change estimates. In postmenopausal Chinese women, CEE with or without MPA was not associated with increased rates of coronary heart disease, but was CEE with MPA may be associated with a higher breast cancer rate. E+P exposure conferred lower global index event rates.
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影响因子：
--
作者：
Zhang, XL;Shu, XO;Zheng, W
通讯作者：
Zheng, W
影响因子：
--
作者：
Grodstein, Francine;Manson, JoAnn E.;Rexrode, Kathryn
通讯作者：
Rexrode, Kathryn
影响因子：
5
作者：
MICKEY, RM;GREENLAND, S
通讯作者：
GREENLAND, S
影响因子：
5
作者：
Prentice, Ross L.;Chlebowski, Rowan T.;Anderson, Garnet L.
通讯作者：
Anderson, Garnet L.
影响因子：
120.7
作者：
Rossouw, Jacques E.;Prentice, Ross L.;Stefanick, Marcia L.
通讯作者：
Stefanick, Marcia L.