Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine.
Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine.
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纳米材料介导的自噬：生物医学中并存的危害和健康益处
DOI：
10.1186/s12989-020-00372-0
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发表时间：
2020-10-16
影响因子：
10
通讯作者：
Shao L
中科院分区：
文献类型：
--
作者：
Feng X;Zhang Y;Zhang C;Lai X;Zhang Y;Wu J;Hu C;Shao L
纳米材料具有独特的物理化学性质，其广泛的生物医学应用增加了人类接触纳米材料的风险。自噬对调节机体的生理或病理活动具有重要意义，在纳米颗粒驱动的体内和体外生物效应中都起着关键作用。纳米颗粒介导的自噬在生物医学中的危害和健康益处是不可忽视的，需要我们特别关注。我们收集了有关纳米颗粒介导的自噬在体内和体外的毒性作用的研究。一般情况下，NMs可以通过不同的给药途径进入动物模型，或通过不同的摄取途径被细胞内化，对组织、器官、细胞和细胞器造成不同程度的损伤，最终沉积在体内或排出体外。此外，NMs的其他生物学效应，如氧化应激、炎症、坏死、焦亡、铁亡等，都与自噬有关，并协同调节机体活动。因此，我们强调纳米颗粒介导的自噬是一把双刃剑，可用于治疗某些与自噬功能障碍相关的疾病，如癌症、神经退行性疾病和心血管疾病。为了提高纳米颗粒介导的自噬的生物安全性评价，促进纳米颗粒的广泛应用，本文提出了纳米颗粒介导的自噬进一步研究的挑战和建议。利用PubMed和Web of Science等数据库搜索相关文献，其中包括所有已发表的、印刷前的Epub、正在处理的和未索引的引文。本文就纳米颗粒介导的自噬在生物医学领域的双重作用作一综述。利用纳米颗粒介导的自噬的益处来治疗临床疾病，如癌症和神经退行性疾病已成为一种趋势。了解纳米颗粒介导的自噬在生物医学中的调控机制，也有助于尽可能地降低纳米颗粒的毒性作用。
Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.
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影响因子：
2.2
作者：
Behnam MA;Emami F;Sobhani Z;Dehghanian AR
通讯作者：
Dehghanian AR
DOI：
10.1007/s10482-017-0930-7
发表时间：
2018-01-01
影响因子：
2.6
作者：
Bhattacharyya, Purnita;Agarwal, Bikash;Tribedi, Prosun
通讯作者：
Tribedi, Prosun
硫化铜纳米板选择性去势抵抗性前列腺癌光热消融
影响因子：
2.1
作者：
Chen, Jun;Wang, Zhao-jie;Hu, Xiao-yong
通讯作者：
Hu, Xiao-yong
影响因子：
3.4
作者：
Bleeker, Eric A. J.;de Jong, Wim H.;Oomen, Agnes G.
通讯作者：
Oomen, Agnes G.
DOI：
10.1158/1541-7786.mcr-11-0098
发表时间：
2011-09
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Bae H;Guan JL
通讯作者：
Guan JL