Norepinephrine-induced glycerol release from adipose tissue: influence of age and body mass index in obese people.
Norepinephrine-induced glycerol release from adipose tissue: influence of age and body mass index in obese people.
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去甲肾上腺素诱导的脂肪组织甘油释放：肥胖人群年龄和体重指数的影响。
DOI：
10.1016/s0899-9007(01)00608-6
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
Jenkinson,CP
中科院分区：
文献类型：
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作者：
Flechtner-Mors,M;Alt,A;Adler,G;Ditschuneit,HH;Jenkinson,CP
方法受试者160例，男35例，女125例，年龄41.2±11.1岁（19-75岁），体重指数（BMI）为44.8± 8.1kg/m2（26.0- 75.3kg/m2）。收缩压和舒张压分别为149.5±25和93.8±16 mmHg。空腹胰岛素浓度为220.0±202.3 pM，空腹血糖浓度为6.2±2.2 mM，血浆甘油三酯和尿酸值分别为2.4±1.2 mM和326±73 μM。结果基础甘油水平在微透析期间保持不变（F= 0.524，P= 0.888;图1A），并且在受试者之间没有差异（F= 1.6，P= 0.228）。去甲肾上腺素刺激脂解时，甘油流出量显著增加（F= 226.0，P< 0.001）。图2显示了基础和去甲肾上腺素刺激的脂解与年龄（图2A）或BMI（图2B）之间的相关性。基础甘油浓度与年龄或BMI之间的相关性不显著（年龄：r= 0.1316，P= 0.0001）。我们通过微透析技术检测了超重或肥胖受试者的皮下脂肪组织中年龄或BMI与肾上腺素能刺激的脂解作用之间的关系。未观察到去甲肾上腺素刺激的脂解与年龄之间的关系。这些发现不同于以前的报告钝化去甲肾上腺素介导的反应，在老年人与年轻的瘦男性。7我们调查了160名男女受试者，年龄范围很广，
MethodsSubjects (n= 160; 125 female and 35 male) were aged 41.2±11.1 y (range= 19–75 y), with BMI of 44.8±8.1 kg/m 2 (range= 26.0–75.3 kg/m 2). Systolic and diastolic blood pressures were 149.5±25 and 93.8±16 mmHg, respectively. The fasting insulin concentration was 220.0±202.3 pM and the fasting blood glucose concentration was 6.2±2.2 mM. The plasma values for triacylglycerols and uric acid were 2.4±1.2 mM and 326±73 μM, respectively. All values are presented as mean±standardResultsBasal glycerol levels remained unchanged during microdialysis (F= 0.524, P= 0.888; Fig. 1A) and did not differ across subjects (F= 1.6, P= 0.228). When lipolysis was stimulated with norepinephrine, glycerol outflow increased significantly (F= 226.0, P< 0.001). Figure 2 shows the correlation between basal and norepinephrine-stimulated lipolysis with age (Fig. 2A) or BMI (Fig. 2B). Correlations between basal glycerol concentration and age or BMI were not significant (age: r= 0.1316, P=DiscussionWe examined the relation between age or BMI and adrenergically stimulated lipolysis in human subcutaneous adipose tissue of overweight or obese subjects as measured by the microdialysis technique. No relation was observed between norepinephrine-stimulated lipolysis and age. These findings differ from those of a previous report on blunted norepinephrine-mediated responses in elderly versus young lean men. 7 We investigated 160 subjects, of both sexes, over a wide age range and observed a great
影响因子：
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作者：
J. Ostman;S. Efendić;P. Arner
通讯作者：
P. Arner
影响因子：
15.9
作者：
JANSSON, PA;LARSSON, A;LONNROTH, P
通讯作者：
LONNROTH, P
影响因子：
15.9
作者：
LONNQVIST, F;NYBERG, B;ARNER, P
通讯作者：
ARNER, P