Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review.
Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review.
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DOI：
10.3389/fped.2023.1112812
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发表时间：
2023
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然由于担心早发性脓毒症而在出生时迅速开始使用抗生素是常见的，但它通常导致许多早产儿尽管血培养阴性仍暴露于治疗。早期接触抗生素会影响肠道微生物的发育，使婴儿患多种疾病的风险增加。坏死性小肠结肠炎（NEC）是一种影响早产儿的毁灭性炎症性肠病，是研究最广泛的新生儿疾病之一，与早期抗生素有关。虽然一些研究表明NEC的风险增加，但其他研究表明，早期使用抗生素可降低NEC的风险。使用动物模型的研究也产生了不同的结果，即早期抗生素暴露对后续NEC易感性的益处与危害。因此，我们试图进行这一叙述性综述，以帮助澄清早产儿早期抗生素暴露与未来NEC风险之间的关系。我们的目标是：（1）总结人类和动物研究的结果，这些研究调查了早期抗生素和NEC之间的关系，（2）强调这些研究的重要局限性，（3）探索可以解释为什么早期抗生素可能增加或减少NEC风险的潜在机制，（4）确定未来的研究方向。
While prompt initiation of antibiotics at birth due to concerns for early onset sepsis is common, it often leads to many preterm infants being exposed to treatment despite negative blood cultures. Such exposure to early antibiotics can impact the developing gut microbiome putting infants at increased risk of several diseases. Necrotizing enterocolitis (NEC), a devastating inflammatory bowel disease that affects preterm infants, is among the most widely studied neonatal disease that has been linked to early antibiotics. While some studies have demonstrated an increased risk of NEC, other studies have demonstrated seemingly contrary findings of decreased NEC with early antibiotics. Studies using animal models have also yielded differing findings of benefit vs. harm of early antibiotic exposure on subsequent NEC susceptibility. We thus sought to conduct this narrative review to help clarify the relationship between early antibiotics exposure and future risk of NEC in preterm infants. Our objectives are to: (1) summarize findings from human and animal studies that investigated the relationship between early antibiotics and NEC, (2) highlight important limitations of these studies, (3) explore potential mechanisms that can explain why early antibiotics may increase or decrease NEC risk, and (4) identify future directions for research.
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影响因子：
3
作者：
Chen, Wen-Yin;Lo, Yu-Cheng;Hung, Miao-Chiu
通讯作者：
Hung, Miao-Chiu
影响因子：
30.3
作者：
Caballero S;Kim S;Carter RA;Leiner IM;Sušac B;Miller L;Kim GJ;Ling L;Pamer EG
通讯作者：
Pamer EG
DOI：
10.1073/pnas.0401710101
发表时间：
2004-05-11
影响因子：
11.1
作者：
Claud, EC;Lu, L;Cherayil, BJ
通讯作者：
Cherayil, BJ
影响因子：
4.5
作者：
Chaaban H;Patel MM;Burge K;Eckert JV;Lupu C;Keshari RS;Silasi R;Regmi G;Trammell M;Dyer D;McElroy SJ;Lupu F
通讯作者：
Lupu F
影响因子：
5.1
作者：
EGAN, EA;MANTILLA, G;EITZMAN, DV
通讯作者：
EITZMAN, DV