Salvage surgery and microsurgical reconstruction for recurrence of skull base osteosarcoma after carbon ion radiotherapy
Salvage surgery and microsurgical reconstruction for recurrence of skull base osteosarcoma after carbon ion radiotherapy
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碳离子放射治疗后颅底骨肉瘤复发的挽救手术及显微外科重建
DOI：
10.18999/nagjms.77.4.667
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发表时间：
2015
影响因子：
0.9
通讯作者：
Y. Kamei
中科院分区：
文献类型：
--
作者：
K. Kohyama;Kenji Yamada;H. Sugiura;I. Hyodo;Taijiro Ozawa;Y. Hasegawa;Hisakazu Kato;Y. Kamei
摘要碳离子放射治疗是近年来出现的头颈部恶性肿瘤的一种替代治疗方法。然而，它仍处于婴儿阶段，它对随后的抢救手术的影响尚不清楚。在此，我们报告一位43岁女性，在接受碳离子放射治疗后，因左侧额骨骨肉瘤复发而接受挽救手术。肿瘤切除的范围很广，包括被认为受到碳离子放射损伤的组织。硬脑膜缺损采用阔筋膜移植加带蒂盖盖骨瓣修复。采用前臂放射状皮瓣吻合同侧颈部的股前外侧皮瓣修复软组织缺损。由于患者没有出现术后伤口并发症，她能够及早开始辅助化疗。碳离子放射治疗因其集中分布和较强的生物学效应而受到人们的重视。虽然受影响的范围可能有限，但其高效力可能会严重损害邻近的正常组织，并导致严重的术后并发症。尽管有这些担忧，但在此案中取得了令人满意的结果。
ABSTRACT Carbon ion radiotherapy has recently emerged as an alternative choice of treatment for malignant tumors of the head and neck. However, it is still in the infant stages and its influence on subsequent salvage surgery remains unclear. Here we report the case of a 43-year-old woman who underwent salvage surgery for left frontal bone osteosarcoma recurrence following carbon ion radiotherapy. Tumor resection was performed with a wide margin including the tissue considered to have been damaged by carbon ion radiotherapy. The dural defect was reconstructed using a fascia lata graft and pedicled galeal pericranial flap. The soft tissue defect was reconstructed using an anterolateral thigh flap anastomosed to the ipsilateral neck interposed by the radial forearm flap. As the patient developed no postoperative wound complications, she was able to initiate adjuvant chemotherapy early. Carbon ion radiotherapy is useful for its focused distribution and strong biological effects. Although the affected field may be limited, its high potency may severely damage adjacent normal tissue and lead to serious postoperative complications. Despite these concerns, satisfactory results were achieved in this case.
西野理子：“数据档案视角下的NFR98”家庭社会学研究12(2. 35-45 (2001))。
DOI：
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发表时间：
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DOI：
10.1016/s0360-3016(00)00568-x
发表时间：
2000-08-01
影响因子：
7
作者：
Suzuki, M;Kase, Y;Ando, K
通讯作者：
Ando, K
DOI：
10.1016/s0360-3016(98)00544-6
发表时间：
1999-04-01
影响因子：
7
作者：
Kanai, T;Endo, M;Kawachi, K
通讯作者：
Kawachi, K