Impacts of High Environmental Temperatures on Congenital Anomalies: A Systematic Review.
Impacts of High Environmental Temperatures on Congenital Anomalies: A Systematic Review.
复制标题
DOI：
10.3390/ijerph18094910
复制
发表时间：
2021-05-05
影响因子：
--
通讯作者：
Climate Change And Heat-Health Study Group
中科院分区：
文献类型：
--
作者：
Haghighi MM;Wright CY;Ayer J;Urban MF;Pham MD;Boeckmann M;Areal A;Wernecke B;Swift CP;Robinson M;Hetem RS;Chersich MF;Climate Change And Heat-Health Study Group
尽管动物数据和其他证据表明可能存在这种联系，但热暴露与先天性异常之间的联系尚未得到详细探讨。我们回顾了来自PubMed和Web of Science的关于高温和先天性异常的文章，筛选了14880篇关于怀孕期间环境高温暴露和先天性异常的文章。纳入了13项研究。大多数研究在北美(8)或中东(3)进行。方法的多样性是相当大的，包括在温度测量，妊娠期暴露窗口，和范围的缺陷研究。在六项研究中，有三项研究发现了热暴露与先天性心脏异常之间的关联，其中心房间隔缺陷的点估计最高。两项研究使用了自我报告的温度暴露，结果为零。尿道下裂、先天性白内障、肾发育不全/发育不全、脊柱裂和颅面缺陷也与热暴露有关。影响一般随热暴露的持续时间和强度而增加。然而，一些神经管缺陷、胃裂、眼盲/小眼和先天性甲状腺功能减退症在高温下较少发生。虽然研究结果各不相同，但证据引起了人们对热暴露和出生缺陷的重要关注。一些异质性可以用生殖流行病学的偏差来解释。利用先天性异常记录对热影响进行汇总分析是当务之急。
Links between heat exposure and congenital anomalies have not been explored in detail despite animal data and other strands of evidence that indicate such links are likely. We reviewed articles on heat and congenital anomalies from PubMed and Web of Science, screening 14,880 titles and abstracts in duplicate for articles on environmental heat exposure during pregnancy and congenital anomalies. Thirteen studies were included. Most studies were in North America (8) or the Middle East (3). Methodological diversity was considerable, including in temperature measurement, gestational windows of exposure, and range of defects studied. Associations were detected between heat exposure and congenital cardiac anomalies in three of six studies, with point estimates highest for atrial septal defects. Two studies with null findings used self-reported temperature exposures. Hypospadias, congenital cataracts, renal agenesis/hypoplasia, spina bifida, and craniofacial defects were also linked with heat exposure. Effects generally increased with duration and intensity of heat exposure. However, some neural tube defects, gastroschisis, anopthalmia/microphthalmia and congenital hypothyroidism were less frequent at higher temperatures. While findings are heterogenous, the evidence raises important concerns about heat exposure and birth defects. Some heterogeneity may be explained by biases in reproductive epidemiology. Pooled analyses of heat impacts using registers of congenital anomalies are a high priority.
登录
查看更多内容
影响因子：
3.4
作者：
Martinez Garcia, Daniel;Sheehan, Mary C.
通讯作者：
Sheehan, Mary C.
影响因子：
11.8
作者：
Lin S;Lin Z;Ou Y;Soim A;Shrestha S;Lu Y;Sheridan S;Luben TJ;Fitzgerald E;Bell E;Shaw GM;Reefhuis J;Langlois PH;Romitti P;Feldkamp ML;Malik S;Pantea C;Nayak S;Hwang SA;Browne M;National Birth Defects Prevention Study
通讯作者：
National Birth Defects Prevention Study
影响因子：
5.6
作者：
Kerr SM;Parker SE;Mitchell AA;Tinker SC;Werler MM
通讯作者：
Werler MM
影响因子：
2.8
作者：
Judge, CM;Chasan-Taber, L;Marshall, EG
通讯作者：
Marshall, EG
影响因子：
10.4
作者：
Auger N;Fraser WD;Sauve R;Bilodeau-Bertrand M;Kosatsky T
通讯作者：
Kosatsky T