Important determinants for fucoidan bioactivity: a critical review of structure-function relations and extraction methods for fucose-containing sulfated polysaccharides from brown seaweeds.
Important determinants for fucoidan bioactivity: a critical review of structure-function relations and extraction methods for fucose-containing sulfated polysaccharides from brown seaweeds.
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岩藻依氨基生物活性的重要决定因素：对棕色海藻中含有岩藻糖硫化的多糖的结构功能关系和提取方法的批判性回顾。
作者：
Ale MT;Mikkelsen JD;Meyer AS
海藻——或海洋巨藻——特别是褐藻纲的棕色海藻，含有褐藻聚糖。岩藻多糖指的是一组含有特定焦糖的硫酸酸化多糖（fcsp），其骨架由（1→3）连接的α-l-岩藻多糖或（1→3）-和（1→4）连接的α-l-岩藻多糖残基交替构成，但也包括以（1→6）-β-d-半乳糖-和/或（1→2）-β-d-甘露糖吡喃糖基为骨架，具有焦糖或岩藻低聚糖分支，和/或葡萄糖醛酸、木糖或葡萄糖取代的硫酸酸化半乳糖聚糖。这些fsps为人类提供了几种潜在的有益生物活性功能。生物活性特性可能因海藻的来源、组成和结构特征、硫酸盐取代物的含量（电荷密度）、分布和键合以及FCSP产品的纯度而异。保存FCSP分子的结构完整性基本上取决于提取方法，这对于获得特定生物活性所需的相关结构特征以及阐明结构-功能关系具有至关重要但部分被忽视的意义。本文综述了岩藻糖聚糖/ fsp化学的最新进展，重点介绍了不同提取技术对其结构组成和生物活性的影响，特别是对硫酸盐基团的影响。
Seaweeds—or marine macroalgae—notably brown seaweeds in the class Phaeophyceae, contain fucoidan. Fucoidan designates a group of certain fucose-containing sulfated polysaccharides (FCSPs) that have a backbone built of (1→3)-linked α-l-fucopyranosyl or of alternating (1→3)- and (1→4)-linked α-l-fucopyranosyl residues, but also include sulfated galactofucans with backbones built of (1→6)-β-d-galacto- and/or (1→2)-β-d-mannopyranosyl units with fucose or fuco-oligosaccharide branching, and/or glucuronic acid, xylose or glucose substitutions. These FCSPs offer several potentially beneficial bioactive functions for humans. The bioactive properties may vary depending on the source of seaweed, the compositional and structural traits, the content (charge density), distribution, and bonding of the sulfate substitutions, and the purity of the FCSP product. The preservation of the structural integrity of the FCSP molecules essentially depends on the extraction methodology which has a crucial, but partly overlooked, significance for obtaining the relevant structural features required for specific biological activities and for elucidating structure-function relations. The aim of this review is to provide information on the most recent developments in the chemistry of fucoidan/FCSPs emphasizing the significance of different extraction techniques for the structural composition and biological activity with particular focus on sulfate groups.
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DOI：
10.1039/jr9500000827
发表时间：
1950-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY
影响因子：
--
作者：
CONCHIE, J;PERCIVAL, EGV
通讯作者：
PERCIVAL, EGV
影响因子：
3.3
作者：
Hemmingson, J. A.;Falshaw, R.;Thompson, K.
通讯作者：
Thompson, K.
影响因子：
3.1
作者：
Bilan, MI;Grachev, AA;Usov, AI
通讯作者：
Usov, AI
影响因子：
5.8
作者：
Grossi, Francesco;Kubota, Kaoru;Douillard, Jean-Yves
通讯作者：
Douillard, Jean-Yves
影响因子：
4.1
作者：
Bird, GM;Haas, P
通讯作者：
Haas, P