Sex-specific immune mechanisms in PTSD symptomatology and risk: A translational overview and perspectives.
Sex-specific immune mechanisms in PTSD symptomatology and risk: A translational overview and perspectives.
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DOI：
10.1016/j.brainresbull.2023.02.013
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发表时间：
2023-04
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
创伤后应激障碍(PTSD)患者免疫功能的改变可能在PTSD的发病机制中起一定作用。女性更容易患上创伤后应激障碍，这表明男性和女性创伤后应激障碍的患病率和风险存在潜在的性别特异性炎症机制。在这篇综述中，我们检查了现有的文献，以更好地评估该领域的知识状况。在人类中，患有创伤后应激障碍的男性和女性的全身炎症都会增加，但女性似乎更严重。尽管很少有临床研究将性别作为观察到的创伤后应激障碍免疫变化的一个因素，但人类性别特异性免疫功能的研究面临的挑战包括：控制混杂变量，如创伤类型和种族；研究中枢神经系统(CNS)相关变化的方法有限。因此，临床前研究是一个有价值的工具，可以为我们提供关于创伤后应激障碍背后的性别特异性外周和中枢神经系统免疫机制的关键见解。现有的临床前研究报告说，在雄性和雌性啮齿动物中，全身和中枢神经系统炎症增加，单核细胞从外周到大脑的转运增加。到目前为止，心理创伤引起的炎症在雌性啮齿动物中比在雄性啮齿动物中更强烈。临床前研究的局限性包括几乎不适用于雌性啮齿动物的动物模型，以及可能影响免疫功能的动情期激素变化。本综述：(1)强调人类和动物研究的关键发现；(2)提供解决局限性的指导；以及(3)讨论在大脑、神经血管和系统单位之间更复杂的相互作用方面的知识差距。
Altered immune function in patients with posttraumatic stress disorder (PTSD) may play a role in the disorder pathophysiology and onset. Women are more likely to develop PTSD, suggesting potential sex-specific inflammatory mechanisms underlying the dichotomous prevalence and risk of PTSD in men and women. In this review we examine the available literature to better assess the state of knowledge in the field. In humans, increased systemic inflammation is found in both men and women with PTSD, but seems to be at a greater extend in women. Despite the existence of few clinical studies taking account of sex as a factor in the observed immune changes in PTSD, challenges in the study of sex-specific immune function in humans include: controlling for confounding variates such as the type of trauma and the ethnicity; and limited methodologies available to study central nervous system (CNS)-relevant changes. Thus, preclinical studies are a valuable tool to provide us with key insights on sex-specific peripheral and CNS immune mechanisms underlying PTSD. Available preclinical studies reported increased systemic and CNS inflammation, as well as elevated trafficking of monocytes from the periphery to the brain in both male and female rodents. To date, psychological trauma-induced inflammation is more robust in female vs male rodents. Limitations of preclinical studies include animal models hardly applicable to female rodents, and hormonal changes across estrus phases that may affect immune function. The present review: (1) highlights the key findings from both human and animal studies, (2) provides guidance to address limitations; and (3) discuss the gap of knowledge on a more complex intertwined interaction between the brain, neurovascular, and systemic units.
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影响因子：
3.8
作者：
Heath, Nicole M.;Chesney, Samantha A.;Gerhart, James I.;Goldsmith, Rachel E.;Luborsky, Judith L.;Stevens, Natalie R.;Hobfoll, Stevan E.
通讯作者：
Hobfoll, Stevan E.
影响因子：
9.3
作者：
Barnum CJ;Pace TW;Hu F;Neigh GN;Tansey MG
通讯作者：
Tansey MG
影响因子：
25.8
作者：
Eraly, Satish A.;Nievergelt, Caroline M.;Maihofer, Adam X.;Barkauskas, Donald A.;Biswas, Nilima;Agorastos, Agorastos;O'Connor, Daniel T.;Baker, Dewleen G.
通讯作者：
Baker, Dewleen G.
影响因子：
2.3
作者：
Green, B
通讯作者：
Green, B
DOI：
10.1080/15374416.2020.1823849
发表时间：
2020-10-10
影响因子：
4.2
作者：
Danzi, BreAnne A.;La Greca, Annette M.
通讯作者：
La Greca, Annette M.