Interpersonal violence, PTSD, and inflammation: potential psychogenic pathways to higher C-reactive protein levels.
Interpersonal violence, PTSD, and inflammation: potential psychogenic pathways to higher C-reactive protein levels.
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DOI：
10.1016/j.cyto.2013.04.030
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发表时间：
2013-08
期刊：
影响因子：
3.8
通讯作者：
Hobfoll, Stevan E.
中科院分区：
文献类型：
--
作者：
Heath, Nicole M.;Chesney, Samantha A.;Gerhart, James I.;Goldsmith, Rachel E.;Luborsky, Judith L.;Stevens, Natalie R.;Hobfoll, Stevan E.
人际暴力（IPV）是主要的公共卫生问题，具有广泛的后遗症，包括抑郁症，创伤后应激障碍（PTSD），以及免疫和炎症过程的可能改变。有必要确定IPV可能转化为改变的炎症过程的心理生物学途径，因为PTSD和炎症都与严重的身体健康状况有关，如肥胖，糖尿病和心血管疾病。本研究调查了IPV，心理困扰和炎症标志物C-反应蛋白（CRP）之间的关系，在139个城市妇女谁有很高的可能性经历过IPV的样本。参与者从妇科门诊招募，完成关于他们IPV历史和心理症状的自我报告措施，以及使用手指针刺采集血液样本。结果表明，暴露于IPV预测可能的抑郁症和PTSD诊断的存在。经历临床水平PTSD的个体表现出更高的CRP水平，并且这种关系在调整共病抑郁症后仍然存在。相关性分析表明，再次经历症状可能解释PTSD诊断和CRP水平升高之间的联系。后续路径分析模型提供了良好的拟合的整体数据，并表明可能的PTSD状态和CRP之间的关系是不能解释较高的BMI。总的来说，这些发现呼吁人们更多地关注创伤后应激障碍在解释创伤和健康下降之间联系方面的作用。
Interpersonal violence (IPV) is major public health concern with wide-ranging sequelae including depression, posttraumatic stress disorder (PTSD), and possible alterations of immune and inflammation processes. There is a need to identify the psycho-biological pathways through which IPV may translate to altered inflammatory processes since both PTSD and inflammation are associated with serious physical health conditions such as obesity, diabetes, and cardiovascular disease. This study investigated the relationships between IPV, psychological distress, and the inflammatory marker C-reactive protein (CRP), in a sample of 139 urban women who have a high likelihood for having experienced IPV. Participants were recruited from an outpatient gynecology clinic to complete self-report measures about their IPV histories and psychological symptoms, as well as to have their blood sampled using a finger stick. Results indicated that exposure to IPV predicted the presence of probable depression and PTSD diagnoses. Individuals who experience clinical levels of PTSD exhibited higher CRP levels, and this relationship held after adjusting for comorbid depression. Correlational analyses suggested that reexperiencing symptoms may explain the link between PTSD diagnosis and higher levels of CRP. Follow-up path analytic models provided good fit to the overall data, and indicated that the relationship between probable PTSD status and CRP is not explained by higher BMI. Overall, these findings call for increased attention to the role of PTSD in explaining links between trauma and diminished health.
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通讯作者：
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