Alterations of grey matter volumes and network-level functions in patients with stable chronic obstructive pulmonary disease
Alterations of grey matter volumes and network-level functions in patients with stable chronic obstructive pulmonary disease
复制标题
稳定型慢性阻塞性肺疾病患者灰质体积和网络水平功能的变化
DOI：
10.1016/j.neulet.2020.134748
复制
发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
SHIYUAN LIU
中科院分区：
文献类型：
--
作者：
WEI WANG;PENG WANG;QINGCHU LI;ZHAOHUI PENG;XIANG WANG;GANG WANG;JINGMING HOU;LI FAN;SHIYUAN LIU
ObjectiveThe purpose of this study was to investigate structural and functional alterations of the brain in the patients with stable chronic obstructive pulmonary disorder (COPD) and further investigate how these alterations correlated to parameters of pulmonary function test, cognitive function and disease duration in patients with COPD.MethodForty-five patients with stable COPD and forty age- and gender-matched healthy controls were enrolled into this study. Both resting-state fMRI and structural MRI were acquired for each participant. Voxel-based morphology was utilized to analyze alterations of the grey matter volume (GMV), and the seed-based resting-state functional connectivity (FC) was used to evaluate the network-level functional alterations.ResultsCompared to healthy controls, patients with stable COPD showed decreased GMV in the left supramarginal gyrus/precentral gyrus (SMG/PreCG), bilateral posterior midcingulate cortex (pMCC), right middle occipital gyrus (MOG) and right SMG. Furthermore, COPD patients mainly showed decreased FC within the visual network, frontoparietal network and other brain regions. Subsequent correlational analyses revealed that the decreased FC within visual network, frontoparietal network were positively correlated with the Montreal Cognitive Assessment score, language-domain score, attention-domain score and disease duration in patients with COPD.ConclusionOur findings provided evidence that COPD patients showed decreased GMV and regional and network-level functional alterations within the visual network, frontoparietal network and other networks. We speculated that atrophic GMV and FC of visual network and frontoparietal network are involved in the neural mechanism of mild cognitive impairment in stable COPD patients.
登录
查看更多内容
影响因子：
3.7
作者：
Wang J;Fan Y;Dong Y;Ma M;Ma Y;Dong Y;Niu Y;Jiang Y;Wang H;Wang Z;Wu L;Sun H;Cui C
通讯作者：
Cui C
DOI：
10.1523/jneurosci.5609-08.2009
发表时间：
2009-04-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Shulman GL;Astafiev SV;Franke D;Pope DL;Snyder AZ;McAvoy MP;Corbetta M
通讯作者：
Corbetta M
影响因子：
3.2
作者：
Laird AR;Fox PM;Eickhoff SB;Turner JA;Ray KL;McKay DR;Glahn DC;Beckmann CF;Smith SM;Fox PT
通讯作者：
Fox PT
DOI：
10.1016/b978-0-12-391924-3.00024-7
发表时间：
2013-01-01
期刊：
NEUROSCIENCE OF AUTISM SPECTRUM DISORDERS
影响因子：
--
作者：
Buxbaum, Joseph D.;Hof, Patrick R.
通讯作者：
Hof, Patrick R.
DOI：
10.2147/copd.s190671
发表时间：
2019-02
影响因子：
2.8
作者：
Huizhen Xin;Haijun Li;Honghui Yu;Jingjing Yu;Juan Zhang;Wenjing Wang;Dechang Peng
通讯作者：
Huizhen Xin;Haijun Li;Honghui Yu;Jingjing Yu;Juan Zhang;Wenjing Wang;Dechang Peng