Alterations in Brain Structure and Functional Connectivity in Alcohol Dependent Patients and Possible Association with Impulsivity.
Alterations in Brain Structure and Functional Connectivity in Alcohol Dependent Patients and Possible Association with Impulsivity.
复制标题
DOI：
10.1371/journal.pone.0161956
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Cui C
中科院分区：
文献类型：
--
作者：
Wang J;Fan Y;Dong Y;Ma M;Ma Y;Dong Y;Niu Y;Jiang Y;Wang H;Wang Z;Wu L;Sun H;Cui C
Previous studies have documented that heightened impulsivity likely contributes to the development and maintenance of alcohol use disorders. However, there is still a lack of studies that comprehensively detected the brain changes associated with abnormal impulsivity in alcohol addicts. This study was designed to investigate the alterations in brain structure and functional connectivity associated with abnormal impulsivity in alcohol dependent patients. Brain structural and functional magnetic resonance imaging data as well as impulsive behavior data were collected from 20 alcohol dependent patients and 20 age- and sex-matched healthy controls respectively. Voxel-based morphometry was used to investigate the differences of grey matter volume, and tract-based spatial statistics was used to detect abnormal white matter regions between alcohol dependent patients and healthy controls. The alterations in resting-state functional connectivity in alcohol dependent patients were examined using selected brain areas with gray matter deficits as seed regions. Compared with healthy controls, alcohol dependent patients had significantly reduced gray matter volume in the mesocorticolimbic system including the dorsal posterior cingulate cortex, the dorsal anterior cingulate cortex, the medial prefrontal cortex, the orbitofrontal cortex and the putamen, decreased fractional anisotropy in the regions connecting the damaged grey matter areas driven by higher radial diffusivity value in the same areas and decreased resting-state functional connectivity within the reward network. Moreover, the gray matter volume of the left medial prefrontal cortex exhibited negative correlations with various impulse indices. These findings suggest that chronic alcohol dependence could cause a complex neural changes linked to abnormal impulsivity.
登录
查看更多内容
影响因子：
10.6
作者：
Heitzeg, Mary M.;Nigg, Joel T.;Yau, Wai-Ying Wendy;Zucker, Robert A.;Zubieta, Jon-Kar
通讯作者：
Zubieta, Jon-Kar
影响因子：
3.4
作者：
Dick DM;Smith G;Olausson P;Mitchell SH;Leeman RF;O'Malley SS;Sher K
通讯作者：
Sher K
DOI：
10.1111/j.1530-0277.2010.01217.x
发表时间：
2010-08
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Lejuez CW;Magidson JF;Mitchell SH;Sinha R;Stevens MC;de Wit H
通讯作者：
de Wit H
影响因子：
25.8
作者：
Hu, Yuzheng;Salmeron, Betty Jo;Yang, Yihong
通讯作者：
Yang, Yihong
影响因子：
3.7
作者：
Forbes EE;Rodriguez EE;Musselman S;Narendran R
通讯作者：
Narendran R